Skip to Main content Skip to Navigation
Journal articles

DRD2: Bridging the Genome and Ingestive Behavior

Abstract : Recent work highlights the importance of genetic variants that influence brain structure and function in conferring risk for polygenic obesity. The neurotransmitter dopamine (DA) has a pivotal role in energy balance by integrating metabolic signals with circuits supporting cognitive, perceptual, and appetitive functions that guide feeding. It has also been established that diet and obesity alter DA signaling, leading to compulsive-like feeding and neurocognitive impairments. This raises the possibility that genetic variants that influence DA signaling and adaptation confer risk for overeating and cognitive decline. Here, we consider the role of two common gene variants, FTO and TaqIA rs1800497 in driving gene x environment interactions promoting obesity, metabolic dysfunction, and cognitive change via their influence on DA receptor subtype 2 (DRD2) signaling.
Document type :
Journal articles
Complete list of metadata
Contributor : Colette ORANGE Connect in order to contact the contributor
Submitted on : Wednesday, January 13, 2021 - 9:42:46 AM
Last modification on : Wednesday, July 28, 2021 - 9:57:58 AM

Links full text




X Sun, S Luquet, Dm Small. DRD2: Bridging the Genome and Ingestive Behavior. Trends in Cognitive Sciences, Elsevier, 2017, 21 (5), pp.372-384. ⟨10.1016/j.tics.2017.03.004⟩. ⟨hal-03108254⟩



Record views