Effect of lyophilized prune extract on hyperhomocysteinemia in mice - Archive ouverte HAL Access content directly
Journal Articles Food and Chemical Toxicology Year : 2017

Effect of lyophilized prune extract on hyperhomocysteinemia in mice

(1) , (2) , (3) , (4) , (1) , (2)
1
2
3
4

Abstract

Altered homocysteine metabolism defined as hyperhomocysteinemia is implicated as pathogenic factor in several cardiovascular diseases and atherosclerosis. The purpose of this study was to investigate the efficacy of prune extract, a good source of phenolic antioxidants, on lowering plasma homocysteine level in male hyperhomocysteinemic mice from average weight of 28 g. The administration of lyophilized prune extract was carried out by intraperitoneal injection one day preceding and one hour before sacrifice of mice. Prune extract decreased significantly plasma homocysteine level, correlated with an increased activity of S-adenosylhomocysteine (SAH) hydrolase and NAD(P)H: quinone oxydoreductase-1 activities. Our results suggest a beneficial effect of prune extract on hyperhomocysteinemia with reduction of homocysteine level by its conversion on to SAH by S-adenosylhomocysteine hydrolase, which is activated by NAD(+), a by-product of NAD(P)H: quinone oxydo reductase-1. (C) 2017 Elsevier Ltd. All rights reserved.
Fichier principal
Vignette du fichier
j.fct.2017.03.018 (2).pdf (787.54 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03108248 , version 1 (17-11-2022)

Identifiers

Cite

H Haddadi-Guemghar, A Tlili, J Dairou, Jl Paul, K Madani, et al.. Effect of lyophilized prune extract on hyperhomocysteinemia in mice. Food and Chemical Toxicology, 2017, 103, pp.183-187. ⟨10.1016/j.fct.2017.03.018⟩. ⟨hal-03108248⟩
10 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More