Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction - Archive ouverte HAL Access content directly
Journal Articles FASEB Journal Year : 2018

Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction

, , , , , , (1) ,
1
A Reichenbach
  • Function : Author
R Stark
  • Function : Author
M Mequinion
  • Function : Author
Sh Lockie
  • Function : Author
Mb Lemus
  • Function : Author
Rl Mynatt
  • Function : Author
Zb Andrews
  • Function : Author

Abstract

Hunger-sensing agouti-related peptide (AgRP) neurons ensure survival by adapting metabolism and behavior to low caloric environments. This adaption is accomplished by consolidating food intake, suppressing energy expenditure, and maximizing fat storage (nutrient partitioning) for energy preservation. The intracellular mechanisms responsible are unknown. Here we report that AgRP carnitine acetyltransferase (Crat) knockout (KO) mice exhibited increased fatty acid utilization and greater fat loss after 9 d of calorie restriction (CR). No differences were seen in mice with ad libitum food intake. Eleven days ad libitum feeding after CR resulted in greater food intake, rebound weight gain, and adiposity in AgRP Crat KO mice compared with wild-type controls, as KO mice act to restore pre-CR fat mass. Collectively, this study highlights the importance of Crat in AgRP neurons to regulate nutrient partitioning and fat mass during chronically reduced caloric intake. The increased food intake, body weight gain, and adiposity in KO mice after CR also highlights the detrimental and persistent metabolic consequence of impaired substrate utilization associated with CR. This finding may have significant implications for postdieting weight management in patients with metabolic diseases.Reichenbach, A., Stark, R., Mequinion, M., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Luquet, S., Andrews, Z. B. Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction.
Fichier principal
Vignette du fichier
fj.201800634R.pdf (1.64 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03105464 , version 1 (16-11-2022)

Identifiers

Cite

A Reichenbach, R Stark, M Mequinion, Sh Lockie, Mb Lemus, et al.. Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction. FASEB Journal, 2018, 32 (12), pp.6923-6933. ⟨10.1096/fj.201800634R⟩. ⟨hal-03105464⟩
7 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More