Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity

Anne-Florence Blandin (1) , Aurélie Durand (1) , Marie Litzler (1) , Aurélien Tripp (1) , Eric Guérin (1) , Elisa Ruhland (2) , Adeline Obrecht (3) , Céline Keime (4) , Quentin Fuchs (5) , Damien Reita (1, 5) , Benoit Lhermitte (6, 5, 7) , Andres Coca (8) , Chris Jones (9) , Isabelle Rebel (5) , Pascal Villa (3) , Izzie Namer (3) , Monique Dontenwill (5) , Dominique Guenot (10, 1) , Natacha Entz-Werle (11, 5)

1 Laboratory EA3430. Progression tumorale et microenvironnement, Approches Translationnelles et Epidémiologie, University of Strasbourg, 3 avenue Molière, 67000 Strasbourg, France
2 Biophysique et médecine nucléaire Hôpitaux Universitaires de Strasbourg
3 PCBiS - Plate-forme de chimie biologique intégrative de Strasbourg
4 CGPhiMC - Centre de génétique et de physiologie moléculaire et cellulaire
5 LBP - Laboratoire de Bioimagerie et Pathologies
6 Pathology Department, University Hospital of Strasbourg, 1 avenue Molière, 67098 Strasbourg, France
7 Centre de Ressources Biologiques, CRB, University Hospital of Strasbourg, 1 avenue Molière, 67098 Strasbourg, France
8 Neurosurgery, University Hospital of Strasbourg, 1 avenue Molière, 67098 Strasbourg, France
9 The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SW7 3RP, UK
10 IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
11 Pediatric Onco-Hematology Department, Pediatrics, University hospital of Strasbourg, 1 avenue Molière, 67098 Strasbourg, France

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Cancer

Anne-Florence Blandin, Aurélie Durand, Marie Litzler, Aurélien Tripp, Eric Guérin, et al.. Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity. Cancers, 2019, 11 (12), pp.1875. ⟨10.3390/cancers11121875⟩. ⟨hal-03098718⟩