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Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery
It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.
Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery
It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.
Marianna Porcino
Charlotte Martineau-Corcos
Weifeng Zhu
Gilles Patriarche
Christine Péchoux
Barbara Perronne
Alia Hassan
Rainer Kümmerle
Alexandre Michelet
Anne Zehnacker-Rentien
Kena Zhao
Tao Guo
Caifen Wang
Yong Zhou
Ting Xiong
Li Wu
Xue Li
1
Priyanka Mittal
Senlin Shi
Ruxandra Gref
1
Jiwen Zhang
Marianna Porcino
Author
Charlotte Martineau-Corcos
Author
Weifeng Zhu
Author
Gilles Patriarche
Author
Christine Péchoux
Author Employer institution : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement IdHAL : christine-longin ORCID : https://orcid.org/0000-0002-3850-2888
Barbara Perronne
Author
Alia Hassan
Author
Rainer Kümmerle
Author
Alexandre Michelet
Author
Anne Zehnacker-Rentien
Author IdHAL : anne-zehnacker ORCID : https://orcid.org/0000-0001-5540-0667 ResearcherId : http://www.researcherid.com/rid/D-3052-2016
Kena Zhao
Author
Tao Guo
Author
Jiwen Zhang
Author
1
ISMO - Institut des Sciences Moléculaires d'Orsay (Université Paris-Sud 91405 Orsay cedex - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8214 (France)
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Journal articles
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https://hal-cnrs.archives-ouvertes.fr/hal-03095979
Contributor : Ruxandra Gref <>
Submitted on : Monday, January 4, 2021 - 6:24:41 PM
Last modification on : Friday, February 26, 2021 - 6:46:04 PM
Contributor : Ruxandra Gref <>
Submitted on : Monday, January 4, 2021 - 6:24:41 PM
Last modification on : Friday, February 26, 2021 - 6:46:04 PM
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- HAL Id : hal-03095979, version 1
- DOI : 10.1016/j.apsb.2020.04.015
Citation
Marianna Porcino, Charlotte Martineau-Corcos, Weifeng Zhu, Gilles Patriarche, Christine Péchoux, et al.. Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery. Acta Pharmaceutica Sinica B, Elsevier, 2020, 10 (9), pp.1709-1718. ⟨10.1016/j.apsb.2020.04.015⟩. ⟨hal-03095979⟩
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