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High Pathogenicity of Nipah Virus from Pteropus lylei Fruit Bats, Cambodia
Abstract : We conducted an in-depth characterization of the Nipah virus (NiV) isolate previously obtained from a Pteropus lylei bat in Cambodia in 2003 (CSUR381). We performed full-genome sequencing and phylogenetic analyses and confirmed CSUR381 is part of the NiV-Malaysia genotype. In vitro studies revealed similar cell permissiveness and replication of CSUR381 (compared with 2 other NiV isolates) in both bat and human cell lines. Sequence alignments indicated conservation of the ephrin-B2 and ephrin-B3 receptor binding sites, the glycosylation site on the G attachment protein, as well as the editing site in phosphoprotein, suggesting production of nonstructural proteins V and W, known to counteract the host innate immunity. In the hamster animal model, CSUR381 induced lethal infections. Altogether, these data suggest that the Cambodia bat-derived NiV isolate has high pathogenic potential and, thus, provide insight for further studies and better risk assessment for future NiV outbreaks in Southeast Asia.
https://hal-cnrs.archives-ouvertes.fr/hal-03091393
Contributor : Cyrille Mathieu <>
Submitted on : Thursday, December 31, 2020 - 12:17:18 AM
Last modification on : Monday, January 18, 2021 - 9:34:05 AM
Contributor : Cyrille Mathieu <>
Submitted on : Thursday, December 31, 2020 - 12:17:18 AM
Last modification on : Monday, January 18, 2021 - 9:34:05 AM
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