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Chromosomal resolution reveals symbiotic virus colonization of parasitic wasp genomes

Jérémy Gauthier 1 Hélène Boulain 1 Joke J.F.A. van Vugt Lyam Baudry 2, 3 Emma Persyn Jean-Marc Aury 4, 5 Benjamin Noel Anthony Bretaudeau 6, 7 Fabrice Legeai Sven Warris Mohamed Amine Chebbi Géraldine Dubreuil 1 Bernard Duvic 8 Natacha Kremer 9 Philippe Gayral 1 Karine Musset 1 Thibaut Josse 1 Diane Bigot Christophe Bressac 1 Sébastien Moreau 1 Georges Périquet Myriam Harry 10 Nicolas Montagne 11 Isabelle Boulogne Mahnaz Sabeti-Azad Martine Maïbèche 11 Thomas Chertemps Frédérique Hilliou 12 David Siaussat 11 Joëlle Amselem 13 Isabelle Luyten Claire Capdevielle-Dulac 10 Karine Labadie Bruna Laís Merlin Valérie Barbe 14 Jetske de Boer Martial Marbouty 2, 3 Fernando Luis Cônsoli Stéphane Dupas 10 Aurélie Hua Van 10 Gaëlle Le Goff 12 Annie Bézier 1 Emmanuelle Jacquin-Joly 11 James Whitfield Louise E.M. Vet 15 Hans Smid Laure Kaiser 10 Romain Koszul 2 Elisabeth Huguet 1 Elisabeth A. Herniou 1 Jean-Michel Drezen 1, * 
Abstract : Most endogenous viruses, an important proportion of eukaryote genomes, are doomed to slowly decay. Little is known, however, on how they evolve when they confer a benefit to their host. Bracoviruses are essential for the parasitism success of parasitoid wasps, whose genomes they integrated ~103 million years ago. Here we show, from the assembly of a parasitoid wasp genome, for the first time at a chromosomal scale, that symbiotic bracovirus genes spread to and colonized all the chromosomes. Moreover, large viral clusters are stably maintained suggesting strong evolutionary constraints. Genomic comparison with another wasps revealed that this organization was already established ~53 mya. Transcriptomic analyses highlight temporal synchronization of viral gene expression, leading to particle production. Immune genes are not induced, however, indicating the virus is not perceived as foreign by the wasp. This recognition suggests that no conflicts remain between symbiotic partners when benefits to them converge.
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Submitted on : Wednesday, December 30, 2020 - 10:56:12 AM
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Jérémy Gauthier, Hélène Boulain, Joke J.F.A. van Vugt, Lyam Baudry, Emma Persyn, et al.. Chromosomal resolution reveals symbiotic virus colonization of parasitic wasp genomes. 2020. ⟨hal-03090838⟩



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