Implication of gut microbiota metabolites in cardiovascular and metabolic diseases - Archive ouverte HAL Access content directly
Journal Articles Cellular and Molecular Life Sciences Year : 2018

Implication of gut microbiota metabolites in cardiovascular and metabolic diseases

(1) , (1) , (2, 3, 4) , (5)
1
2
3
4
5

Abstract

Evidence from the literature keeps highlighting the impact of mutualistic bacterial communities of the gut microbiota on human health. The gut microbita is a complex ecosystem of symbiotic bacteria which contributes to mammalian host biology by processing, otherwise, indigestible nutrients, supplying essential metabolites, and contributing to modulate its immune system. Advances in sequencing technologies have enabled structural analysis of the human gut microbiota and allowed detection of changes in gut bacterial composition in several common diseases, including cardiometabolic disorders. Biological signals sent by the gut microbiota to the host, including microbial metabolites and pro-inflammatory molecules, mediate microbiome-host genome cross-talk. This rapidly expanding line of research can identify disease-causing and diseasepredictive microbial metabolite biomarkers, which can be translated into novel biodiagnostic tests, dietary supplements, and nutritional interventions for personalized therapeutic developments in common diseases. Here, we review results from the most significant studies dealing with the association of products from the gut microbial metabolism with cardiometabolic disorders. We underline the importance of these postbiotic biomarkers in the diagnosis and treatment of human disorders.
Fichier principal
Vignette du fichier
Brial2018_Article_ImplicationOfGutMicrobiotaMeta.pdf (1.12 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-03089369 , version 1 (28-12-2020)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Francois Brial, Aurelie Le Lay, Marc-Emmanuel Dumas, Dominique Gauguier. Implication of gut microbiota metabolites in cardiovascular and metabolic diseases. Cellular and Molecular Life Sciences, 2018, 75 (21), pp.3977 - 3990. ⟨10.1007/s00018-018-2901-1⟩. ⟨hal-03089369⟩
21 View
25 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More