HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function

Abstract : Exposure to natural metabolites contributes to the risk of cardiometabolic diseases (CMDs). Through metabolome profiling, we identify the inverse correlation between serum concentrations of 4-cresol and type 2 diabetes. The chronic administration of non-toxic doses of 4-cresol in complementary preclinical models of CMD reduces adiposity, glucose intolerance, and liver triglycerides, enhances insulin secretion in vivo, stimulates islet density and size, and pancreatic β-cell proliferation, and increases vascularization, suggesting activated islet enlargement. In vivo insulin sensitivity is not affected by 4-cresol. The incubation of mouse isolated islets with 4-cresol results in enhanced insulin secretion, insulin content, and β-cell proliferation of a magnitude similar to that induced by GLP-1. In both CMD models and isolated islets, 4-cresol is associated with the downregulated expression of the kinase DYRK1A, which may mediate its biological effects. Our findings identify 4-cresol as an effective regulator of β-cell function, which opens up perspectives for therapeutic applications in syndromes of insulin deficiency.
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03089353
Contributor : Marc-Emmanuel Dumas Connect in order to contact the contributor
Submitted on : Monday, December 28, 2020 - 12:20:46 PM
Last modification on : Thursday, April 7, 2022 - 1:58:32 PM
Long-term archiving on: : Monday, March 29, 2021 - 6:42:16 PM

File

1-s2.0-S2211124720300917-main....
Publisher files allowed on an open archive

Identifiers

Citation

Francois Brial, Fawaz Alzaid, Kazuhiro Sonomura, Yoichiro Kamatani, Kelly Meneyrol, et al.. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Reports, Elsevier Inc, 2020, 30 (7), pp.2306-2320.e5. ⟨10.1016/j.celrep.2020.01.066⟩. ⟨hal-03089353⟩

Share

Metrics

Record views

86

Files downloads

22