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Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

Abstract : DNA methylation is essential to development and cellular physiology in mammals. Faulty DNA methylation is frequently observed in human diseases like cancer and neurological disorders. Molecularly, this epigenetic mark is linked to other chromatin modifications and it regulates key genomic processes, including transcription and splicing. Each round of DNA replication generates two hemi-methylated copies of the genome. These must be converted back to symmetrically methylated DNA before the next Sphase, or the mark will fade away; therefore the maintenance of DNA methylation is essential. Mechanistically, the maintenance of this epigenetic modification takes place during and after DNA replication, and occurs within the very dynamic context of chromatin reassembly. Here, we review recent discoveries and unresolved questions regarding the mechanisms, dynamics and fidelity of DNA methylation maintenance in mammals. We also discuss how it could be regulated in normal development and misregulated in disease.
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https://hal-cnrs.archives-ouvertes.fr/hal-03063725
Contributor : Pierre-Antoine Defossez Connect in order to contact the contributor
Submitted on : Monday, December 14, 2020 - 11:12:57 AM
Last modification on : Wednesday, October 27, 2021 - 7:13:41 AM
Long-term archiving on: : Monday, March 15, 2021 - 7:03:58 PM

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Nataliya Petryk, Sebastian Bultmann, Till Bartke, Pierre-Antoine Defossez. Staying true to yourself: mechanisms of DNA methylation maintenance in mammals. Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa1154⟩. ⟨hal-03063725⟩

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