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Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation

Abstract : Pea3 proteins belong to a subfamily of the E-twenty six (ETS) domain superfamily of transcription factors, which play various roles during developmental processes. Polyoma Enhancer-Activator 3 (Pea3) proteins Pea3, ERM and Er81 are particularly involved in tissues with branching morphogenesis, including kidney, lung, mammary gland and nervous system development. A recent transcriptomic study on novel targets of Pea3 transcription factor has revealed various axon guidance and nervous system development related targets, supporting role of Pea3 proteins in specific motor neuron connectivity, as well as novel targets in signaling pathways involved in synaptic plasticity. This study focuses on the expression of Pea3 family members in hippocampal neurons, and regulation of putative Pea3 targets in Pea3-overexpressing cell lines and following Long Term Potentiation (LTP) or seizure induction in vivo. We show that Pea3 proteins are expressed in hippocampus in both neuronal and non-neuronal cells, and that Pea3 represses Elk-1 but activates Prkca and Nrcam expression in hippocampal cell lines. We also show that mRNA and protein levels of Pea3 family members are differentially regulated in the dentate gyrus and CA1 region upon MECS stimulation, but not LTP.
Keywords : Pea3 hippocampus LTP
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Submitted on : Tuesday, December 8, 2020 - 11:31:07 AM
Last modification on : Wednesday, January 26, 2022 - 3:33:47 AM
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Başak Kandemir, Sabrina Davis, Esra Nur Yiğit, Gürkan Öztürk, Bayram Yilmaz, et al.. Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation. Neuroscience Letters, Elsevier, 2020, 738, ⟨10.1016/j.neulet.2020.135348⟩. ⟨hal-03045987⟩



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