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Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Yahya Ashraf Hanane Mansouri Valérie Laurent-Matha Lindsay Alcaraz Pascal Roger Séverine Guiu Danielle Derocq Gautier Robin Henri-Alexandre Michaud Helène Delpech Marta Jarlier Martine Pugnière Bruno Robert Anthony Puel Lucie Martin Flavie Landomiel Thomas Bourquard Oussama Achour Ingrid Fruitier-Arnaudin Alexandre Pichard Emmanuel Deshayes Andrei Turtoi Anne Poupon 1, 2, 3 Joëlle Simony-Lafontaine Florence Boissière-Michot Nelly Pirot Florence Bernex William Jacot Stanislas Du Manoir Charles Theillet Jean-Pierre Pouget Isabelle Navarro-Teulon Nathalie Bonnefoy André Pèlegrin Thierry Chardès Pierre Martineau Emmanuelle Liaudet-Coopman
1 CNRS - Centre National de la Recherche Scientifique
2 MUSCA - Dynamiques de populations multi-échelles pour des systèmes physiologiques
Inria Saclay - Ile de France, PRC - Physiologie de la reproduction et des comportements [Nouzilly], MaIAGE - Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas]
3 MAbSilico SAS
Abstract : Background: Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumorspecific molecular targets and/or alternative therapeutic strategies for TNBC are urgently needed. Immunotherapy is emerging as an exciting treatment option for TNBC patients. The aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer (BC), is overproduced and hypersecreted by human BC cells. This study explores whether cath-D is a tumor cell-associated extracellular biomarker and a potent target for antibody-based therapy in TNBC.
Mots-clés : biologie computationnelle
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Journal articles
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https://hal-cnrs.archives-ouvertes.fr/hal-03039856
Contributor : Anne Poupon <>
Submitted on : Friday, December 4, 2020 - 9:35:33 AM
Last modification on : Monday, July 19, 2021 - 4:18:11 PM
Long-term archiving on: : Friday, March 5, 2021 - 6:21:25 PM

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Yahya Ashraf, Hanane Mansouri, Valérie Laurent-Matha, Lindsay Alcaraz, Pascal Roger, et al.. Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies. Journal for Immunotherapy of Cancer, BMJ Publishing Group 2019, 7, ⟨10.1186/s40425-019-0498-z⟩. ⟨hal-03039856⟩

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