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Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context
Abstract : Scope: Scope: It is well established that immune response and inflammation promote tumoral progression. Immune cells communicate through direct contact or through cytokine secretion, and it is the pro-inflammatory status that will tip the balance toward tumor progression or anti-tumor immunity. It is demonstrated here that a red wine extract (RWE) can decrease inflammation through its action on the inflammasome complex. This study determines whether an RWE could impact other key actors of inflammation, including T helper 17 (Th17) immune cells in particular. Methods and results: Methods and results: Using an RWE containing 4.16 g of polyphenols/liter of wine, it is shown that RWE decreases colorectal cancer cells in vitro and induces a reduction in colorectal tumor growth associated with a decrease in tumor-infiltrating lymphocytes in vivo. The process of T-lymphocyte differentiation in Th17 cells is altered by RWE, as revealed by the decrease in the expression of key actors controlling this process, such as signal transducer and activator of transcription 3 and retinoid acid-related orphan receptor t. This disruption is associated with an inhibition of inflammatory interleukin 17 secretion. Conclusion: The data highlights the major involvement of Th17 immune cells in the biological effects of an RWE.
Keywords :
Polyphenols
lymphocytes Th17
lymphocyte T Red wine extract
chemoprevention
colon cancer
red wine extract
Cancers polyphenols
Dominique
Cancers Delmas
Virginie
Cancers Lipids
Fanny
Plateforme de Transfert en Biologie du Cancer (PTBC) Chalmin
Cancers
Emeric
Cancers Limagne
Flavie
Cancers Courtaut
Nutrition
Lipids
Interleukins
https://hal-cnrs.archives-ouvertes.fr/hal-03033795
Contributor : Cyril Auger <>
Submitted on : Tuesday, December 22, 2020 - 4:06:58 PM
Last modification on : Monday, January 4, 2021 - 11:21:10 AM
Contributor : Cyril Auger <>
Submitted on : Tuesday, December 22, 2020 - 4:06:58 PM
Last modification on : Monday, January 4, 2021 - 11:21:10 AM
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