Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice

Vincent Le Moigne (1) , Clément Raynaud (2) , Flavie Moreau (3) , Christian Dupont , Jérôme Nigou (3) , Olivier Neyrolles (3) , Laurent Kremer (2) , Jean-Louis Herrmann (1, 4)

1 2I - Infection et inflammation
2 IRIM - Institut de Recherche en Infectiologie de Montpellier
3 IPBS - Institut de pharmacologie et de biologie structurale
4 Hôpital Raymond Poincaré [AP-HP]

Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics such as bedaquiline and imipenem although in vitro data have questioned this combination. We report that the efficacy of the bedaquiline plus imipenem treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus. The addition of imipenem contributed at clearing the infection in the spleen.

Keywords: Cystic fibrosis; Mycobacterium abscessus; Imipenem; Bedaquiline; C3HeB/FeJ mice

Domains: Life Sciences [q-bio]

Vincent Le Moigne, Clément Raynaud, Flavie Moreau, Christian Dupont, Jérôme Nigou, et al.. Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice. Antimicrobial Agents and Chemotherapy, 2020, 64 (6), ⟨10.1128/AAC.00114-20⟩. ⟨hal-03032987⟩