Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice - Archive ouverte HAL Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2020

Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice

(1) , (2) , (3) , , (3) , (3) , (2) , (1, 4)
1
2
3
4

Abstract

Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics such as bedaquiline and imipenem although in vitro data have questioned this combination. We report that the efficacy of the bedaquiline plus imipenem treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus. The addition of imipenem contributed at clearing the infection in the spleen.
Fichier principal
Vignette du fichier
AAC00114-20R1_Merged_PDF (2).pdf (750.38 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03032987 , version 1 (01-12-2020)

Identifiers

Cite

Vincent Le Moigne, Clément Raynaud, Flavie Moreau, Christian Dupont, Jérôme Nigou, et al.. Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice. Antimicrobial Agents and Chemotherapy, 2020, 64 (6), ⟨10.1128/AAC.00114-20⟩. ⟨hal-03032987⟩
70 View
85 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More