Skip to Main content Skip to Navigation
Journal articles

Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice

Abstract : Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics such as bedaquiline and imipenem although in vitro data have questioned this combination. We report that the efficacy of the bedaquiline plus imipenem treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus. The addition of imipenem contributed at clearing the infection in the spleen.
Document type :
Journal articles
Complete list of metadatas

https://hal-cnrs.archives-ouvertes.fr/hal-03032987
Contributor : Jérôme Nigou <>
Submitted on : Tuesday, December 1, 2020 - 11:26:12 AM
Last modification on : Thursday, January 7, 2021 - 3:37:07 AM

File

AAC00114-20R1_Merged_PDF (2).p...
Files produced by the author(s)

Identifiers

Collections

Citation

Vincent Le Moigne, Clément Raynaud, Flavie Moreau, Christian Dupont, Jérôme Nigou, et al.. Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (6), ⟨10.1128/aac⟩. ⟨hal-03032987⟩

Share

Metrics

Record views

8

Files downloads

11