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Journal articles
Efficacy of bedaquiline, alone or in combination with imipenem, against Mycobacterium abscessusin C3HeB/FeJ mice
Abstract : Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics such as bedaquiline and imipenem although in vitro data have questioned this combination. We report that the efficacy of the bedaquiline plus imipenem treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus. The addition of imipenem contributed at clearing the infection in the spleen.
https://hal-cnrs.archives-ouvertes.fr/hal-03032987
Contributor : Jérôme Nigou Connect in order to contact the contributor
Submitted on : Tuesday, December 1, 2020 - 11:26:12 AM
Last modification on : Wednesday, November 3, 2021 - 5:38:55 AM
Long-term archiving on: : Tuesday, March 2, 2021 - 6:39:41 PM
Contributor : Jérôme Nigou Connect in order to contact the contributor
Submitted on : Tuesday, December 1, 2020 - 11:26:12 AM
Last modification on : Wednesday, November 3, 2021 - 5:38:55 AM
Long-term archiving on: : Tuesday, March 2, 2021 - 6:39:41 PM
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