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Effects of water restriction on social behavior and 5-HT neurons density in the dorsal and median raphe nuclei in mice

Abstract : We explored here the hypothesis that temporary chronic water restriction in mice affects social behavior, via its action on the density of 5-HT neurons in dorsal and median raphe nuclei (DRN and MRN). For that, we submitted adult C57BL/6 J mice to mild and controlled temporary dehydration, i.e., 6 h of water access every 48 h for 15 days. We investigated their social behavior in a social interaction task known to allow free and reciprocal social contact. Results showed that temporary dehydration increases significantly time spent in social contact and social dominance. It also expands 5-HT neuron density within both DRN and MRN and the behavioral and neuronal plasticity were positively correlated. Our findings suggest that disturbance in 5-HT neurotransmission caused by temporary dehydration stress unbalances choice processes of animals in social context.
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https://hal-cnrs.archives-ouvertes.fr/hal-03029828
Contributor : Alain Perignon <>
Submitted on : Sunday, November 29, 2020 - 10:12:53 AM
Last modification on : Tuesday, December 1, 2020 - 3:46:52 AM

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Houari Boukersi, Nemcha Lebaili, Anne Nosjean, Nathalie Samson, Alexis Faure, et al.. Effects of water restriction on social behavior and 5-HT neurons density in the dorsal and median raphe nuclei in mice. Behavioural Brain Research, Elsevier, 2020, pp.113022. ⟨10.1016/j.bbr.2020.113022⟩. ⟨hal-03029828⟩

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