Sedative, Muscle Relaxant-Like Effects, and Molecular Docking Study of Compounds Isolated from Salvia leriifolia - Archive ouverte HAL Access content directly
Journal Articles Revista Brasileira de Farmacognosia Year : 2020

Sedative, Muscle Relaxant-Like Effects, and Molecular Docking Study of Compounds Isolated from Salvia leriifolia

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Amjad Hussain
  • Function : Author
Abdur Rauf
  • Function : Author
  • PersonId : 1082896
Tareq Abu-Izneid
  • Function : Author
Muhammad Ibrahim
  • Function : Author
Shazia Abrar
  • Function : Author
Haroon Khan
  • Function : Author
Barkath Ullah
  • Function : Author
José Pedro Cerón-Carrasco
  • Function : Author
Horacio Pérez-Sánchez
Muhammad Iqbal Choudhary
  • Function : Author
Mohammad S Mubarak
  • Function : Author
Mohammad Ali Shariati
  • Function : Author
Yahia N Mabkhot
  • Function : Author

Abstract

Salvia leriifolia Benth., Lamiaceae, an endemic medicinal plant of the northern region of Iran, has been documented as sedative. It has been used in traditional medicine for its muscle relaxation effect. The need for sedation and muscle relaxation are common problems which are usually treated with different synthetic drugs, which are associated with severe side effects. The aim of the current study was to investigate the muscle relaxation and sedative potency of compounds isolated from S. leriifolia. Open field and traction tests were employed to study the muscle relaxant and like effects of compounds 1 and 2 isolated from S. leriifolia in mice. Results revealed that each of these compounds (1 and 2) caused a considerable decrease in mice mobility at test doses of 10, 15, and 20 mg/kg i.p. in a dose-dependent manner. When these compounds were tested in the traction test, they exhibited significant dosedependent skeleton muscle relaxation effect during various assessment times. Thus, it is concluded that compounds 1 and 2 exert significant sedative and muscle relaxant-like effects and therefore can be candidates for further detailed biological studies. This study strongly justifies the ethnopharmacological uses of S. leriifolia as sedative and muscle relaxant.
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hal-03024296 , version 1 (25-11-2020)

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  • HAL Id : hal-03024296 , version 1

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Amjad Hussain, Abdur Rauf, Tareq Abu-Izneid, Muhammad Ibrahim, Shazia Abrar, et al.. Sedative, Muscle Relaxant-Like Effects, and Molecular Docking Study of Compounds Isolated from Salvia leriifolia. Revista Brasileira de Farmacognosia, 2020. ⟨hal-03024296⟩

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