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Novel One-Pot Access to Diastereoisomeric Tertiary Phospholanes Oxides by Using Enantiomerically Pure Phospholane Oxides Under Catalyst-Free Conditions

Abstract : For the first time, enantiopure 1-r-oxo-2-c,5-t-diphenylphospholane was introduced as nucleophile in the multicomponent condensation reaction. Diastereoisomers of 2,5-diphenyl-1-oxo-1-[alkylphenyl-1-(phenylamino) methyl] phospholane derivatives were synthesized by one-pot process from aromatic aldehydes, anilines and enantiopure1-r-oxo-2-c,5-t-diphenyl-phospholane under green and eco-compatible conditions. The reaction proceeds under catalyst-free conditions at room temperature within very short time (3 min) in excellent yields (up to 95%). An X-ray crystal structure has been obtained for 2,5-diphenyl-1-oxo-1-[phenyl (phenylamino) methyl] phospholane.
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https://hal-cnrs.archives-ouvertes.fr/hal-03019308
Contributor : Martial Toffano Connect in order to contact the contributor
Submitted on : Wednesday, July 28, 2021 - 10:51:27 AM
Last modification on : Friday, July 30, 2021 - 4:01:52 AM

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Samia Lakoud, Rim Aissa, Regis Guillot, Martial Toffano, L. Aribi‐zouioueche. Novel One-Pot Access to Diastereoisomeric Tertiary Phospholanes Oxides by Using Enantiomerically Pure Phospholane Oxides Under Catalyst-Free Conditions. ChemistrySelect, Wiley, 2020, 5 (1), pp.379-383. ⟨10.1002/slct.201903760⟩. ⟨hal-03019308⟩

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