Skip to Main content Skip to Navigation
Journal articles

Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism

Abstract : Under caloric restriction, bone marrow adipocytes (BM-Ads) do not decrease in size compared to white adipocytes, suggesting they harbor unique metabolic properties. We compare human primary BM-Ads with paired subcutaneous adipocytes (SC-Ads) using proteomic and lipidomic approaches. We find that, although SC-Ads and BM-Ads share similar morphological features, they possess distinct lipid metabolism. Although BM-Ad shows enrichment in proteins involved in cholesterol metabolism, correlating with increased free cholesterol content, proteins involved in lipolysis were downregulated. In particular, monoacylglycerol lipase expression is strongly reduced in BM-Ads, leading to monoacylglycerol accumulation. Consequently, basal and induced lipolytic responses are absent in BM-Ads, affirming their differences in metabolic fitness upon caloric restriction. These specific metabolic features are not recapitulated in vitro using common protocols to differentiate bone marrow mesenchymal stem cells. Thus, contrary to classical SC-Ads, BM-Ads display a specific lipid metabolism, as they are devoid of lipolytic activity and exhibit a cholesterol-orientated metabolism.
Document type :
Journal articles
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03018743
Contributor : Colette Orange Connect in order to contact the contributor
Submitted on : Friday, March 19, 2021 - 4:51:11 PM
Last modification on : Monday, March 22, 2021 - 3:27:41 PM

File

PIIS2211124719317541.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Camille Attané, David Estève, Karima Chaoui, Jason S. Iacovoni, Jill Corre, et al.. Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism. Cell Reports, Elsevier Inc, 2020, 30 (4), pp.949-958.e6. ⟨10.1016/j.celrep.2019.12.089⟩. ⟨hal-03018743⟩

Share

Metrics

Record views

52

Files downloads

39