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Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

Résumé : Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki's disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity of anti-SARS-CoV-2-specific antibodies in MIS-C patients compared to the COVID patient groups; MIS-C predominantly generated IgG Abs specific for the Spike (S) protein but not for the nucleocapsid (N) protein, while both COVID-19 cohorts had anti-S IgG, IgM and IgA Abs, as well as anti-N IgG Abs. Moreover, MIS-C patients had reduced neutralizing activity compared to COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children and adults who develop severe disease, with implications for optimizing treatments based on symptom and age.
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Preprints, Working Papers, ...
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https://hal-cnrs.archives-ouvertes.fr/hal-03010966
Contributor : Cyrille Mathieu <>
Submitted on : Tuesday, November 17, 2020 - 10:13:08 PM
Last modification on : Wednesday, November 18, 2020 - 3:22:59 AM

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Stuart Weisberg, Thomas Connors, Yun Zhu, Matthew Baldwin, Wen-Hsuan Lin, et al.. Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19. 2020. ⟨hal-03010966⟩

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