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Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

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Stuart Weisberg
  • Function : Author
Thomas Connors
  • Function : Author
Yun Zhu
  • Function : Author
Matthew Baldwin
  • Function : Author
Wen-Hsuan Lin
  • Function : Author
Sandeep Wontakal
  • Function : Author
Peter Szabo
  • Function : Author
Steven Wells
  • Function : Author
Pranay Dogra
  • Function : Author
Joshua Gray
  • Function : Author
Emma Idzikowski
  • Function : Author
Francesca Bovier
  • Function : Author
Julia Davis-Porada
  • Function : Author
Rei Matsumoto
  • Function : Author
Maya Meimei Li Poon
  • Function : Author
Michael Chait
  • Function : Author
Didier Decimo
  • Function : Author
Zachary Bitan
  • Function : Author
Francesca La Carpia
  • Function : Author
Stephen Ferrara
  • Function : Author
Emily Mace
  • Function : Author
Joshua Milner
Anne Moscona
Eldad Hod
  • Function : Author
Matteo Porotto
Donna Farber
  • Function : Author

Abstract

Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki's disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity of anti-SARS-CoV-2-specific antibodies in MIS-C patients compared to the COVID patient groups; MIS-C predominantly generated IgG Abs specific for the Spike (S) protein but not for the nucleocapsid (N) protein, while both COVID-19 cohorts had anti-S IgG, IgM and IgA Abs, as well as anti-N IgG Abs. Moreover, MIS-C patients had reduced neutralizing activity compared to COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children and adults who develop severe disease, with implications for optimizing treatments based on symptom and age.
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hal-03010966 , version 1 (30-12-2020)

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Stuart Weisberg, Thomas Connors, Yun Zhu, Matthew Baldwin, Wen-Hsuan Lin, et al.. Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19. 2020. ⟨hal-03010966⟩
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