Skip to Main content Skip to Navigation
Journal articles

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Abstract : Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)3-5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.
Document type :
Journal articles
Complete list of metadata

https://hal-cnrs.archives-ouvertes.fr/hal-03008774
Contributor : Cyrille Mathieu Connect in order to contact the contributor
Submitted on : Wednesday, November 17, 2021 - 2:05:47 PM
Last modification on : Wednesday, November 24, 2021 - 10:29:52 AM

File

36787_2_merged_1603385760.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Stuart Weisberg, Thomas Connors, Yun Zhu, Matthew Baldwin, Wen-Hsuan Lin, et al.. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum. Nature Immunology, Nature Publishing Group, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩. ⟨hal-03008774⟩

Share

Metrics

Record views

37

Files downloads

25