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Journal articles
Crystal structure of the F component of the Panton-Valentine leucocidin
Abstract : Leucocidins and y-hemolysins are bi-component staphylococcal toxins that form lytic transmem-brane pores. Their cytotoxic activities involve the synergistic association of a class S and a class F component, produced as water-soluble monomers which assemble on the surface of specific cells. The structure of the F protein from Panton-Valentine leucocidin, solved at 2.0 A resolution, and sequence alignment suggest that it represents the fold of any secreted protein in this family of toxins. The comparison of this structure to that of the homoheptameric a-hemolysin provides some insights into the molecular events that may occur during pore formation.
Cited literature [30 references]
https://hal-cnrs.archives-ouvertes.fr/hal-03004342
Contributor : Lionel Mourey Connect in order to contact the contributor
Submitted on : Friday, November 20, 2020 - 3:58:48 PM
Last modification on : Thursday, November 25, 2021 - 5:22:04 PM
Contributor : Lionel Mourey Connect in order to contact the contributor
Submitted on : Friday, November 20, 2020 - 3:58:48 PM
Last modification on : Thursday, November 25, 2021 - 5:22:04 PM
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