Crystal structure of the F component of the Panton-Valentine leucocidin

Jean-Denis Pedelacq (1) , Gilles Prevost , Henri Monteil , Lionel Mourey (1) , Jean-Pierre Samama (1)

1 IPBS - Institut de pharmacologie et de biologie structurale

Leucocidins and y-hemolysins are bi-component staphylococcal toxins that form lytic transmem-brane pores. Their cytotoxic activities involve the synergistic association of a class S and a class F component, produced as water-soluble monomers which assemble on the surface of specific cells. The structure of the F protein from Panton-Valentine leucocidin, solved at 2.0 A resolution, and sequence alignment suggest that it represents the fold of any secreted protein in this family of toxins. The comparison of this structure to that of the homoheptameric a-hemolysin provides some insights into the molecular events that may occur during pore formation.

Domains: Life Sciences [q-bio]

Jean-Denis Pedelacq, Gilles Prevost, Henri Monteil, Lionel Mourey, Jean-Pierre Samama. Crystal structure of the F component of the Panton-Valentine leucocidin. J. Med. Microbial, 2000, 290, pp.395 - 401. ⟨hal-03004342⟩