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The molecular puzzle of two-component signaling cascades

Abstract : Two-component systems constitute prevalent signaling pathways in bacteria and mediate a large variety of adaptative cellular responses. Signaling proceeds through His-Asp phosphorelay cascades that involve two central partners, the histidine protein kinase and the response regulator protein. Structural studies have provided insights into some design principles and activation mechanisms of these multi-domain proteins implicated in the control of virulence gene expression in several pathogens. © 2001 Éditions scientifiques et médicales Elsevier SAS two-component systems / signal transduction / functional domains
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Marie Foussard, Stéphanie Cabantous, Jean-Denis Pedelacq, Valérie Guillet, Samuel Tranier, et al.. The molecular puzzle of two-component signaling cascades. Microbes and Infection, Elsevier, 2001, 3 (5), pp.417-424. ⟨10.1016/s1286-4579(01)01390-9⟩. ⟨hal-03004328⟩

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