Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

Guadalupe Ortiz-Muñoz (1) , Michelle Yu , Emma Lefrançais (2) , Beñat Mallavia , Colin Valet , Jennifer Tian , Serena Ranucci , Kristin Wang , Zhe Liu , Nicholas Kwaan , Diana Dawson , Mary Ellen Kleinhenz , Fadi Khasawneh , Peter Haggie , Alan Verkman , Mark Looney

1 UCSF - Department of Medicine, Microbiology and Immunology
2 IPBS - Institut de pharmacologie et de biologie structurale

Domains: Life Sciences [q-bio]; Immunology; Innate immunity; Life Sciences [q-bio]; Human health and pathology; Pulmonology and respiratory tract; Life Sciences [q-bio]; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Human health and pathology; Tissues and Organs [q-bio.TO]

Guadalupe Ortiz-Muñoz, Michelle Yu, Emma Lefrançais, Beñat Mallavia, Colin Valet, et al.. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. Journal of Clinical Investigation, 2020, 130 (4), pp.2041-2053. ⟨10.1172/JCI129635⟩. ⟨hal-02997938⟩