, Ethics, Ethnical and Economical Aspects: A Systematic Review. (Swedish Council on Health Technology Assessment (SBU), 2008.

C. N. Harada, M. C. Natelson-love, and K. Triebel, Normal Cognitive Aging, Clin. Geriatr. Med, vol.29, pp.737-752, 2013.

D. H. Kausler, Learning and Memory in Normal Aging, 1994.

D. Harman, Free radical theory of aging, Mutat. Res, vol.275, pp.257-266, 1992.

E. Mariani, M. C. Polidori, A. Cherubini, and P. Mecocci, Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview, J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci, vol.827, pp.65-75, 2005.

Y. Zhu, P. M. Carvey, and Z. Ling, Age-related changes in glutathione and glutathione-related enzymes in rat brain, Brain Res, vol.1090, pp.35-44, 2006.

A. Terman, B. Gustafsson, and U. T. Brunk, Mitochondrial damage and intralysosomal degradation in cellular aging, Mol. Aspects Med, vol.27, pp.471-482, 2006.

A. Terman, B. Gustafsson, and U. T. Brunk, The lysosomal-mitochondrial axis theory of postmitotic aging and cell death, Chem. Biol. Interact, vol.163, pp.29-37, 2006.

B. Halliwell, Oxidative stress and neurodegeneration: where are we now?, J. Neurochem, vol.97, pp.1634-1658, 2006.

F. Serrano and E. Klann, Reactive oxygen species and synaptic plasticity in the aging hippocampus, Ageing Res. Rev, vol.3, pp.431-443, 2004.

R. C. Malenka and R. A. Nicoll, Long-term potentiation-a decade of progress?, Science, vol.285, pp.1870-1874, 1999.

L. E. Bettio, L. Rajendran, and J. Gil-mohapel, The effects of aging in the hippocampus and cognitive decline, Neurosci. Biobehav. Rev, vol.79, pp.66-86, 2017.

C. A. Barnes, Long-term potentiation and the ageing brain, Philos. Trans. R. Soc. Lond. B. Biol. Sci, vol.358, pp.765-772, 2003.

C. A. Massaad and E. Klann, Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory, Antioxid. Redox Signal, vol.14, pp.2013-2054, 2011.

M. J. Forster, Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain, Proc. Natl. Acad. Sci. USA, vol.93, pp.4765-4769, 1996.

M. M. Nicolle, Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents, Neuroscience, vol.107, pp.415-431, 2001.

M. Kollen, Preserved memory capacities in aged Lou/C/Jall rats, Neurobiol. Aging, vol.31, pp.129-142, 2010.
URL : https://hal.archives-ouvertes.fr/hal-02325230

F. R. Turpin, Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function, Neurobiol. Aging, vol.32, pp.1495-1504, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02325222

K. Bodhinathan, A. Kumar, and T. C. Foster, Intracellular redox state alters NMDA receptor response during aging through Ca2+/ calmodulin-dependent protein kinase II, J. Neurosci. Off. J. Soc. Neurosci, vol.30, pp.1914-1924, 2010.

S. Rose, Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain, Transl. Psychiatry, vol.2, p.134, 2012.

C. Haxaire, Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting D-serinedependent NMDA receptor activation, Aging Cell, vol.11, pp.336-344, 2012.

D. Hu, F. Serrano, T. D. Oury, and E. Klann, Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase, J. Neurosci. Off. J. Soc. Neurosci, vol.26, pp.3933-3941, 2006.

A. Kamsler, A. Avital, V. Greenberger, and M. Segal, Aged SOD overexpressing mice exhibit enhanced spatial memory while lacking hippocampal neurogenesis, Antioxid. Redox Signal, vol.9, pp.181-189, 2007.

Z. Xie and B. R. Sastry, Impairment of long-term potentiation in rats fed with vitamin E-deficient diet, Brain Res, vol.681, pp.193-196, 1995.

E. Curis, Almost all about citrulline in mammals, Amino Acids, vol.29, pp.177-205, 2005.

K. Akashi, C. Miyake, and A. Yokota, Citrulline, a novel compatible solute in drought-tolerant wild watermelon leaves, is an efficient hydroxyl radical scavenger, FEBS Lett, vol.508, pp.438-442, 2001.

K. Lee and Y. Kang, Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells), J. Biomed. Sci, vol.24, p.28, 2017.

Y. Yabuki, Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection, Brain Res, vol.1520, pp.157-167, 2013.

P. Marquet-de-rougé, Citrulline diet supplementation improves specific age-related raft changes in wild-type rodent hippocampus, Age Dordr. Neth, vol.35, pp.1589-1606, 2013.

C. Moinard, S. Walrand, Y. Boirie, and L. Cynober, Therapeutic use of Citrulline in treatment of increased protein carbonylationassociated diseases, 2007.

C. Moinard, Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats, J. Nutr, vol.145, pp.1429-1437, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01850474

D. Nirmaladevi, Neuroprotective effects of bikaverin on H2O2-induced oxidative stress mediated neuronal damage in SH-SY5Y cell line, Cell. Mol. Neurobiol, vol.34, pp.973-985, 2014.

C. R. Fürstenau, I. C. De-souza, and M. R. De-oliveira, The effects of kahweol, a diterpene present in coffee, on the mitochondria of the human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide, Toxicol. Vitro Int. J. Publ. Assoc. BIBRA, vol.61, p.104601, 2019.

C. Zheng, The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells, Chem. Biol. Interact, vol.310, p.108688, 2019.

H. R. Park, Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, BMC Complement. Altern. Med, vol.15, p.171, 2015.

J. B. Watson, M. M. Arnold, Y. Ho, and T. J. Dell, Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes, J. Neurosci. Res, vol.84, pp.1564-1574, 2006.

J. P. Mothet, A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory, Aging Cell, vol.5, pp.267-274, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02325331

C. Breuillard, L. Cynober, and C. Moinard, Citrulline and nitrogen homeostasis: an overview, Amino Acids, vol.47, pp.685-691, 2015.

C. Papadia, S. Osowska, L. Cynober, and A. Forbes, Citrulline in health and disease. Review on human studies, Clin. Nutr. Edinb. Scotl, 2017.

J. M. Robillard, G. R. Gordon, H. B. Choi, B. R. Christie, and B. A. Macvicar, Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult, PloS One, vol.6, p.20676, 2011.

A. Goron, Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms, Clin. Sci. Lond. Engl, vol.131, pp.775-790, 1979.
URL : https://hal.archives-ouvertes.fr/hal-01933092

X. Wang and P. J. Quinn, Vitamin E and its function in membranes, Prog. Lipid Res, vol.38, pp.309-336, 1999.

W. Wang, Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide, J. Ethnopharmacol, vol.134, pp.147-155, 2011.

C. A. Murray and M. A. Lynch, Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus, J. Biol. Chem, vol.273, pp.12161-12168, 1998.

P. Ambrogini, ?-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions, Int. J. Mol. Sci, vol.17, 2016.

D. R. Skvarc, The effect of N-acetylcysteine (NAC) on human cognition -A systematic review, Neurosci. Biobehav. Rev, vol.78, pp.44-56, 2017.

G. Bjelakovic, D. Nikolova, and C. Gluud, Antioxidant supplements and mortality, Curr. Opin. Clin. Nutr. Metab. Care, vol.17, pp.40-44, 2014.

E. A. Klein, Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT), JAMA, vol.306, pp.1549-1556, 2011.

S. Bahri, Citrulline: from metabolism to therapeutic use, Nutr. Burbank Los Angel. Cty. Calif, vol.29, pp.479-484, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00924338

A. Figueroa, A. Wong, and R. Kalfon, Effects of Watermelon Supplementation on Aortic Hemodynamic Responses to the Cold Pressor Test in Obese Hypertensive Adults, Am. J. Hypertens, vol.27, pp.899-906, 2014.

C. Moinard, Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study, Br. J. Nutr, vol.99, pp.855-862, 2008.

X. Zhao, Artemisinin Attenuated Hydrogen Peroxide (H2O2)-Induced Oxidative Injury in SH-SY5Y and Hippocampal Neurons via the Activation of AMPK Pathway, Int. J. Mol. Sci, vol.20, 2019.

J. D. Sweatt, Neural plasticity and behavior -sixty years of conceptual advances, J. Neurochem, vol.139, issue.2, pp.179-199, 2016.

H. Johnson, Increase in alpha-CGRP and GAP-43 in aged motoneurons: a study of peptides, growth factors, and ChAT mRNA in the lumbar spinal cord of senescent rats with symptoms of hindlimb incapacities, J. Comp. Neurol, vol.359, pp.69-89, 1995.

R. L. Spencer, W. K. O'steen, and B. S. Mcewen, Water maze performance of aged Sprague-Dawley rats in relation to retinal morphologic measures, Behav. Brain Res, vol.68, pp.139-150, 1995.

S. Osowska, C. Moinard, N. Neveux, C. Loï, and L. Cynober, Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection, Gut, vol.53, pp.1781-1786, 2004.

G. Ventura, Effect of citrulline on muscle functions during moderate dietary restriction in healthy adult rats, Amino Acids, vol.45, pp.1123-1131, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01957307