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A Computational Model of the Circulating Renin-Angiotensin System and Blood Pressure Regulation

Abstract : The renin-angiotensin system (RAS) is critical in sodium and blood pressure (BP) regulation, and in cardiovascular-renal (CVR) diseases and therapeutics. As a contribution to SAPHIR project, we present a realistic computer model of renin production and circulating RAS, integrated into Guyton's circulatory model (GCM). Juxtaglomerular apparatus, JGA, and Plasma modules were implemented in C ++/M2SL (Multi-formalism Multi-resolution Simulation Library) for fusion with GCM. Matlab optimization toolboxes were used for parameter identification. In JGA, renin production and granular cells recruitment (GCR) are controlled by perfusion pressure (PP), macula densa (MD), angiotensin II (Ang II), and renal sympathetic activity (RSNA). In Plasma, renin and ACE (angiotensin-converting enzyme) activities are integrated to yield Ang I and II. Model vs. data deviation is given as normalized root mean squared error (nRMSE; n points).
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https://hal-cnrs.archives-ouvertes.fr/hal-02988413
Contributor : Patrick Hannaert <>
Submitted on : Wednesday, November 4, 2020 - 5:17:09 PM
Last modification on : Wednesday, November 4, 2020 - 5:17:09 PM

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Patrick Hannaert, François Guillaud. A Computational Model of the Circulating Renin-Angiotensin System and Blood Pressure Regulation. Acta Biotheoretica, Springer Verlag, 2010, 58 (2-3), pp.143-170. ⟨10.1007/s10441-010-9098-5⟩. ⟨hal-02988413⟩

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