M. Chakraborty, S. G. Qiu, K. M. Vasudevan, and V. M. Rangnekar, Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression, Cancer Res, vol.61, pp.7255-7263, 2001.

N. El-guendy and V. M. Rangnekar, Apoptosis by Par-4 in cancer and neurodegenerative diseases, Exp Cell Res, vol.283, pp.51-66, 2003.

A. Nalca, S. G. Qiu, N. El-guendy, S. Krishnan, and V. M. Rangnekar, Oncogenic Ras sensitizes cells to apoptosis by Par-4, J Biol Chem, vol.274, pp.29976-29983, 1999.

F. Sells-stephen, D. P. Wood, . Joshi-barve, . Ss, S. Muthukumar et al., Commonality of apoptosis of the gene programs in androgen-dependent prostate cells, Cell Growth Differs, vol.5, pp.457-466, 1994.

M. P. Mattson, W. Duan, S. L. Chan, and S. Camandola, Par-4: an emerging pivotal player in neuronal apoptosis and neurodegenerative disorders, J Mol Neurosci, vol.13, pp.17-30, 1999.

S. Gurumurthy and V. M. Rangnekar, Par-4 inducible apoptosis in prostate cancer cells, J Cell Biochem, vol.91, pp.504-512, 2004.

M. T. Díaz-meco, M. M. Municio, S. Frutos, P. Sanchez, J. Lozano et al., The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C, Cell, vol.86, pp.777-786, 1996.

M. T. Diaz-meco, M. J. Lallena, A. Monjas, S. Frutos, and J. Moscat, Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis, J Biol Chem, vol.274, pp.19606-19612, 1999.

C. Guo, S. Yu, A. T. Davis, H. Wang, J. E. Green et al., A potential role of nuclear matrixassociated protein kinase CK2 in protection against drug-induced apoptosis in cancer cells, J Biol Chem, vol.276, pp.5992-5999, 2001.

S. F. Sells, S. S. Han, S. Muthukkumar, N. Maddiwar, R. Johnstone et al., Expression and function of the leucine zipper protein Par-4 in apoptosis, Mol Cell Biol, vol.17, pp.3823-3832, 1997.

B. Wang, C. Kline, D. M. Pastor, T. L. Olson, B. Frank et al., Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network, Mol Cancer, vol.9, p.98, 2010.

C. L. Kline, S. S. Shanmugavelandy, M. Kester, and R. B. Irby, Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU, Cancer Biol Ther, vol.8, pp.1831-1837, 2009.

R. W. Johnstone, N. Tommerup, C. Hansen, H. Vissing, and Y. Shi, Mapping of the human PAWR (par-4) gene to chromosome 12q21, Genomics, vol.53, pp.241-243, 1998.

B. G. Schneider, S. Y. Rha, H. C. Chung, J. C. Bravo, R. Mera et al., Regions of allelic imbalance in the distal portion of chromosome 12q in gastric cancer, Mol Pathol, vol.56, pp.141-149, 2003.

M. A. Nagai, G. R. Salaorni, S. Humberto, J. Guerreiro, T. Nonogaki et al., Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer, Int J Oncol, vol.37, pp.41-49, 2010.

S. Boehrer, K. U. Chow, E. Puccetti, M. Ruthardt, S. Godzisard et al., Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia, Hematol J, vol.2, pp.103-107, 2001.

J. Cook, S. Krishnan, S. Ananth, S. F. Sells, Y. Shi et al., Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma, Oncogene, vol.18, pp.1205-1208, 1999.

J. V. Alvarez, T. Pan, J. Ruth, Y. Feng, A. Zhou et al., Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy, Cancer Cell, vol.24, pp.30-44, 2013.

M. Barradas, A. Monjas, M. T. Diaz-meco, M. Serrano, and J. Moscat, The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression, EMBO J, vol.18, pp.6362-6369, 1999.

I. Garcia-cao, A. Duran, M. Collado, M. J. Carrascosa, J. Martin-caballero et al., Tumour-suppression activity of the proapoptotic regulator Par-4, EMBO Rep, vol.6, pp.577-583, 2005.

N. El-guendy, Y. Zhao, S. Gurumurthy, R. Burikhanov, and V. M. Rangnekar, Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells, Mol Cell Biol, vol.23, pp.5516-5525, 2003.

A. De-thonel, A. Bettaieb, C. Jean, G. Laurent, and A. Quillet-mary, Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells, Blood, vol.98, pp.3770-3777, 2001.

I. Leroy, A. De-thonel, and G. Laurent, Quillet-Mary A. Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis, Cell Signal, vol.17, pp.1149-1157, 2005.

P. Chaudhry, M. Singh, S. Parent, and E. Asselin, Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation, Mol Cell Biol, vol.32, pp.826-839, 2012.

T. J. Lee, J. H. Jang, H. J. Noh, E. J. Park, K. S. Choi et al., Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells, J Cell Biochem, vol.109, pp.885-895, 2010.

R. Burikhanov, Y. Zhao, A. Goswami, S. Qiu, S. R. Schwarze et al., The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis, Cell, vol.138, pp.377-388, 2009.

Y. Zhao, R. Burikhanov, J. Brandon, S. Qiu, B. J. Shelton et al., Systemic Par-4 inhibits non-autochthonous tumor growth, Cancer Biol Ther, vol.12, pp.152-157, 2011.

A. Goswami, R. Burikhanov, A. De-thonel, N. Fujita, M. Goswami et al., Binding and phosphorylation of par-4 by akt is essential for cancer cell survival, Mol Cell, vol.20, pp.33-44, 2005.

S. Gurumurthy, A. Goswami, K. M. Vasudevan, and V. M. Rangnekar, Phosphorylation of Par-4 by protein kinase A is critical for apoptosis, Mol Cell Biol, vol.25, pp.1146-1161, 2005.

J. E. Allende and C. C. Allende, Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation, FASEB J, vol.9, pp.313-323, 1995.

F. Meggio and L. Pinna, One-thousand-and-one substrates of protein kinase CK2?, FASEB J, vol.17, pp.349-368, 2003.

M. Daya-makin, J. S. Sanghera, T. L. Mogentale, M. Lipp, J. Parchomchuk et al., Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung, Cancer Res, vol.54, pp.2262-2268, 1994.

M. Gapany, R. A. Faust, S. Tawfic, A. Davis, G. L. Adams et al., Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck, Mol Med, vol.1, pp.659-666, 1995.

U. Munstermann, G. Fritz, G. Seitz, Y. P. Lu, H. R. Schneider et al., Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue, Eur J Biochem, vol.189, pp.251-257, 1990.

S. Yenice, A. T. Davis, S. A. Goueli, A. Akdas, C. Limas et al., Nuclear casein kinase 2 (CK-2) activity in human normal, benign hyperplastic, and cancerous prostate, Prostate, vol.24, pp.11-16, 1994.

E. Landesman-bollag, D. H. Song, R. Romieu-mourez, D. J. Sussman, R. D. Cardiff et al., Protein kinase CK2: signaling and tumorigenesis in the mammary gland, Mol Cell Biochem, vol.227, pp.153-165, 2001.

M. Ruzzene and L. A. Pinna, Addiction to protein kinase CK2: a common denominator of diverse cancer cells?, Biochim Biophys Acta, vol.1804, pp.499-504, 2010.

K. Ahmed, D. A. Gerber, and C. Cochet, Joining the cell survival squad: an emerging role for protein kinase CK2, Trends Cell Biol, vol.12, pp.226-230, 2002.

G. Wang, K. A. Ahmad, and K. Ahmed, Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells, Cancer Res, vol.66, pp.2242-2249, 2006.

S. Desagher, A. Osen-sand, S. Montessuit, E. Magnenat, F. Vilbois et al., Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8, Mol Cell, vol.8, pp.601-611, 2001.

K. Izeradjene, L. Douglas, A. Delaney, and J. Houghton, Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines, Oncogene, vol.24, pp.2050-2058, 2005.

R. Ravi and A. Bedi, Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II, Cancer Res, vol.62, pp.4180-4185, 2002.

G. Wang, G. Unger, K. A. Ahmad, J. W. Slaton, and K. Ahmed, Downregulation of CK2 induces apoptosis in cancer cells-a potential approach to cancer therapy, Mol Cell Biochem, vol.274, pp.77-84, 2005.

G. Wang, K. A. Ahmad, G. Unger, J. W. Slaton, and K. Ahmed, CK2 signaling in androgen-dependent and -independent prostate cancer, J Cell Biochem, vol.99, pp.382-391, 2006.

G. Wang, K. A. Ahmad, N. H. Harris, and K. Ahmed, Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells, Mol Cell Biochem, vol.316, pp.91-97, 2008.

M. Popescu, Z. Gurel, R. T. Song, C. Hung, K. Y. Payne et al., Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1, J Biol Chem, vol.284, pp.13869-13880, 2009.

M. Ruzzene, D. Penzo, and L. A. Pinna, Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells, Biochem J, vol.364, pp.41-47, 2002.

S. Sarno, H. Reddy, F. Meggio, M. Ruzzene, S. P. Davies et al., Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 (casein kinase-2), FEBS Lett, vol.496, pp.44-48, 2001.

D. Maira, G. Brustolon, F. Bertacchini, J. Tosoni, K. Marmiroli et al., Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level, Oncogene, vol.26, pp.6915-6926, 2007.

K. Izeradjene, L. Douglas, A. Delaney, and J. Houghton, Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells, Clin Cancer Res, vol.10, pp.6650-6660, 2004.

J. W. Slaton, G. M. Unger, D. T. Sloper, A. T. Davis, and K. Ahmed, Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model, Mol Cancer Res, vol.2, pp.712-721, 2004.

M. A. Mcdonnell, M. J. Abedin, M. Melendez, T. N. Platikanova, J. R. Ecklund et al., Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8, J Biol Chem, vol.283, pp.20149-20158, 2008.

A. Krippner-heidenreich, R. V. Talanian, R. Sekul, R. Kraft, H. Thole et al., Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1, Biochem J, vol.358, pp.705-715, 2001.

G. Matsumoto, K. Wada, M. Okuno, M. Kurosawa, and N. Nukina, Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins, Mol Cell, vol.44, pp.279-289, 2011.

G. D. Bren, K. N. Pennington, and C. V. Paya, PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha, J Mol Biol, vol.297, pp.1245-1258, 2000.

S. Chang, J. H. Kim, and J. Shin, p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition, FEBS Lett, vol.510, pp.57-61, 2002.

K. A. Ahmad, G. Wang, J. Slaton, G. Unger, and K. Ahmed, Targeting CK2 for cancer therapy, Anticancer Drugs, vol.16, pp.1037-1043, 2005.

P. Schneider, Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins, Methods Enzymol, vol.322, pp.325-345, 2000.

O. Filhol, A. Nueda, V. Martel, D. Gerber-scokaert, M. J. Benitez et al., Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits, Mol Cell Biol, vol.23, pp.975-987, 2003.

V. Kochin, S. Imanishi, and J. E. Eriksson, Fast track to a phosphoprotein sketch-MALDI-TOF characterization of TLC-based tryptic phosphopeptide maps at femtomolar detection sensitivity, Proteomics, vol.6, pp.5676-5682, 2006.