HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

Phox2a defines a developmental origin of the anterolateral system in mice and humans

Résumé : Anterolateral system neurons relay pain, itch and temperature information from the spinal cord to pain-related brain regions, but the differentiation of these neurons and their specific contribution to pain perception remain poorly defined. Here, we show that virtually all mouse spinal neurons that embryonically express the autonomic system-associated Paired-like homeobox 2A (Phox2a) transcription factor innervate nociceptive brain targets, including the parabrachial nucleus and the thalamus. We define Phox2a anterolateral system neuron birth order, migration and differentiation, and uncover an essential role for Phox2a in the development of relay of nociceptive signals from the spinal cord to the brain. Finally, we also demonstrate that the molecular identity of Phox2a neurons is conserved in the human foetal spinal cord. The developmental expression of Phox2a as a uniting feature of anterolateral system neurons suggests a link between nociception and autonomic nervous system function.
Complete list of metadata

Contributor : Yorick Gitton Connect in order to contact the contributor
Submitted on : Wednesday, August 5, 2020 - 3:41:42 PM
Last modification on : Monday, March 14, 2022 - 4:52:08 PM

Links full text



R. Brian Roome, Farin Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, et al.. Phox2a defines a developmental origin of the anterolateral system in mice and humans. 2020. ⟨hal-02912288⟩



Record views