M. Ardourel, N. Demont, F. Debelle, F. Maillet, F. De-billy et al., Rhizobium meliloti lipooligosaccharide nodulation factors: different structural requirements for bacterial entry into target root hair cells and induction of plant symbiotic developmental responses, Plant Cell, vol.6, pp.1357-1374, 1994.
URL : https://hal.archives-ouvertes.fr/hal-02714454

A. Barsch, V. Tellstr?-om, T. Patschkowski, H. K?-uster, and K. Niehaus, Metabolite profiles of nodulated alfalfa plants indicate that distinct stages of nodule organogenesis are accompanied by global physiological adaptations, Molecular Plant-Microbe Interactions, vol.19, pp.998-1013, 2006.

V. A. Benedito, I. Torres-jerez, J. D. Murray, A. Andriankaja, S. Allen et al., A gene expression atlas of the model legume Medicago truncatula, Plant Journal, vol.55, pp.504-513, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02668894

C. Boivin, S. Camut, C. A. Malpica, G. Truchet, and C. Rosenberg, Rhizobium meliloti genes encoding catabolism of trigonelline are induced under symbiotic conditions, Plant Cell, vol.2, pp.1157-1170, 1990.
URL : https://hal.archives-ouvertes.fr/hal-02714735

L. Brocard, M. Schultze, A. Kondorosi, and P. Ratet, T-DNA mutagenesis in the model plant Medicago truncatula: is it efficient enough for legume molecular genetics? CAB reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, vol.1, pp.1-7, 2006.

J. Canonne, S. Froidure-nicolas, and S. Rivas, Phospholipases in action during plant defense signaling, Plant Signaling & Behaviour, vol.6, pp.13-18, 2011.

A. Cebolla, J. M. Vinardell, E. Kiss, B. Olah, F. Roudier et al., The mitotic inhibitor ccs52 is required for endoreduplication and ploidydependent cell enlargement in plants, EMBO Journal, vol.18, pp.4476-4484, 1999.
URL : https://hal.archives-ouvertes.fr/hal-00191037

X. Cheng, J. Wen, M. Tadege, P. Ratet, and K. S. Mysore, Reverse genetics in Medicago truncatula using Tnt1 insertion mutants, Methods in Molecular Biology, vol.678, pp.179-190, 2011.

L. Coque, P. Neogi, C. Pislariu, K. A. Wilson, C. Catalano et al., Transcription of enod8 in Medicago truncatula nodules directs enod8 esterase to developing and mature symbiosomes, Molecular Plant-Microbe Interactions, vol.21, pp.404-410, 2008.

V. Cosson, P. Durand, I. Erfurth, A. Kondorosi, and P. Ratet, Medicago truncatula transformation using leaf explants, Methods in Molecular Biology, vol.343, pp.115-127, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00118503

D. W. Ehrhardt, E. M. Atkinson, and S. R. Long, Depolarization of alfalfa root hair membrane potential by Rhizobium meliloti nod factors, Science, vol.256, pp.998-1000, 1992.

F. El-yahyaoui, H. Kuster, B. Amor, B. Hohnjec, N. Puhler et al., Expression profiling in Medicago truncatula identifies more than 750 genes differentially expressed during nodulation, including many potential regulators of the symbiotic program, Plant Physiology, vol.136, pp.3159-3176, 2004.
URL : https://hal.archives-ouvertes.fr/hal-02683438

I. D'erfurth, V. Cosson, A. Eschstruth, H. Lucas, A. Kondorosi et al., Efficient transposition of the Tnt1 tobacco retrotransposon in the model legume Medicago truncatula, Plant Journal, vol.34, pp.95-106, 2003.

J. Garcia, D. G. Barker, E. P. Journet, M. Baloban, M. Sani et al., Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis, The Medicago truncatula handbook. ISBN 0-9754303-1-9, vol.9, p.1001169, 2006.

T. Hakoyama, K. Niimi, H. Watanabe, R. Tabata, J. Matsubara et al., Host plant genome overcomes the lack of a bacterial gene for symbiotic nitrogen fixation, Nature, vol.462, pp.514-517, 2009.

T. Hakoyama, K. Niimi, T. Yamamoto, S. Isobe, S. Sato et al., The integral membrane protein SEN1 is required for symbiotic nitrogen fixation in Lotus japonicus nodules, Plant and Cell Physiology, vol.53, pp.225-236, 2012.

R. Hardy, R. D. Holsten, E. K. Jackson, and R. C. Burns, The acetylene-ethylene assay for N 2 fixation: laboratory and field evaluation, Plant Physiology, vol.43, pp.1185-1207, 1968.

J. He, V. A. Benedito, M. Wang, J. D. Murray, P. X. Zhao et al., The Medicago truncatula gene expression atlas web server, BMC Bioinformatics, vol.10, p.441, 2009.

D. W. Heinz, L. O. Essen, and R. L. Williams, Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C, Journal of Molecular Biology, vol.275, pp.635-650, 1998.

B. Hoffmann, T. H. Trinh, J. Leung, A. Kondorosi, and E. Kondorosi, A new Medicago truncatula line with superior in vitro regeneration, transformation, and symbiotic properties isolated through cell culture selection, Molecular Plant-Microbe Interactions, vol.10, pp.307-315, 1997.
URL : https://hal.archives-ouvertes.fr/hal-02684412

N. Hohnjec, F. Lenz, V. Fehlberg, M. F. Vieweg, M. C. Baier et al., The signal peptide of the Medicago truncatula modular nodulin Mtnod25 operates as an address label for the specific targeting of proteins to nitrogen-fixing symbiosomes, Molecular Plant-Microbe Interactions, vol.22, pp.63-72, 2009.

A. Iantcheva, M. Chabaud, V. Cosson, M. Barascud, B. Schutz et al., Osmotic shock improves Tnt1 transposition frequency in Medicago truncatula cv jemalong during in vitro regeneration, Plant Cell Reporter, vol.28, pp.1563-1572, 2009.
URL : https://hal.archives-ouvertes.fr/hal-02660696

N. Kinoshita, Y. Ooki, Y. Deguchi, S. A. Chechetka, H. Kouchi et al., Cloning and expression analysis of a mapkkk gene and a novel nodulin gene of Lotus japonicus, Bioscience Biotechnologies Biochemistry, vol.68, pp.1805-1807, 2004.

E. Kondorosi, Z. Banfalvi, and A. Kondorosi, Physical and genetic analysis of a symbiotic region of Rhizobium meliloti: identification of nodulation genes, Molecular and General Genetics, vol.193, pp.445-452, 1984.

L. Krall, U. Wiedemann, G. Unsin, S. Weiss, N. Domke et al., Detergent extraction identifies different Virb protein subassemblies of the type IV secretion machinery in the membranes of Agrobacterium tumefaciens, Proceedings of the National Academy of Sciences, vol.99, pp.11405-11410, 2002.

H. Kumagai, T. Hakoyama, Y. Umehara, S. Sato, T. Kaneko et al., A novel ankyrin-repeat membrane protein, IGN1, is required for persistence of nitrogen-fixing symbiosis in root nodules of Lotus japonicus, Plant Physiology, vol.143, pp.1293-1305, 2007.

C. Lelandais-briere, L. Naya, E. Sallet, F. Calenge, F. Frugier et al., Genome-wide Medicago truncatula small RNA analysis revealed novel microRNAs and isoforms differentially regulated in roots and nodules, Plant Cell, vol.21, pp.2780-2796, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00856243

S. A. Leong, P. H. Williams, and G. S. Ditta, Analysis of the 5' regulatory region of the gene for delta-aminolevulinic acid synthetase of Rhizobium meliloti, Nucleic Acids Research, vol.13, pp.5965-5976, 1985.

J. Liu, S. S. Miller, M. Graham, B. Bucciarelli, C. M. Catalano et al., Recruitment of novel calcium-binding proteins for root nodule symbiosis in Medicago truncatula, Plant Physiology, vol.141, pp.167-177, 2006.

N. Maunoury, M. Redondo-nieto, M. Bourcy, W. Van-de-velde, B. Alunni et al., Differentiation of symbiotic cells and endosymbionts in Medicago truncatula nodulation are coupled to two transcriptome-switches, PLoS ONE, vol.5, p.9519, 2010.
URL : https://hal.archives-ouvertes.fr/hal-02661146

H. M. Meade, S. R. Long, G. B. Ruvkun, S. E. Brown, and F. M. Ausubel, Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis, Journal of Bacteriology, vol.149, pp.114-122, 1982.

M. H. Meckfessel, E. B. Blancaflor, M. Plunkett, Q. Dong, and R. Dickstein, Multiple domains in Mtenod8 protein including the signal peptide target it to the symbiosome, Plant Physiology, vol.159, pp.299-310, 2012.

P. Mergaert, T. Uchiumi, B. Alunni, G. Evanno, A. Cheron et al., Eukaryotic control on bacterial cell cycle and differentiation in the Rhizobium-legume symbiosis, Proceedings of the National Academy of Sciences, vol.103, pp.5230-5235, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00118557

R. H. Michell, Inositol and its derivatives: their evolution and functions, Advances in Enzyme Regulation, vol.51, pp.84-90, 2011.

R. M. Mitra and S. R. Long, Plant and bacterial symbiotic mutants define three transcriptionally distinct stages in the development of the Medicago truncatula/ Sinorhizobium meliloti symbiosis, Plant Physiology, vol.134, pp.595-604, 2004.

S. Moreau, M. Verdenaud, T. Ott, S. Letort, F. De-billy et al., Transcription reprogramming during root nodule development in Medicago truncatula, PLoS ONE, vol.6, p.16463, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02647172

R. L. Nicholson and R. Hammerschmidt, Phenolic compounds and their role in disease resistance, Annual Review of Phytopathology, vol.30, pp.369-389, 1992.

G. Oldroyd, . Ed, J. D. Murray, P. S. Poole, and J. A. Downie, The rules of engagement in the legume-rhizobial symbiosis, Annual Review of Genetics, vol.45, pp.119-144, 2011.

L. Orosz, Z. Svab, A. Kondorosi, and T. Sik, Genetic studies on rhizobiophage 16-3. I. Genes and functions on the chromosome, Molecular General Genetics, vol.125, pp.341-350, 1973.

R. V. Penmetsa and D. R. Cook, A legume ethylene-insensitive mutant hyperinfected by its rhizobial symbiont, Science, vol.275, pp.527-530, 1997.

C. I. Pislariu and R. Dickstein, An IRE-like AGC kinase gene, MtIRE, has unique expression in the invasion zone of developing root nodules in Medicago truncatula, Plant Physiology, vol.144, pp.682-694, 2007.

C. I. Pislariu, J. Murray, J. Wen, V. Cosson, D. Muni et al., A Medicago truncatula tobacco-retrotransposon (Tnt1)-insertion mutant collection with defects in nodule development and symbiotic nitrogen fixation, Plant Physiology, vol.159, pp.1686-1699, 2012.

A. Rakocevic, S. Mondy, L. Tirichine, V. Cosson, L. Brocard et al., MERE1, a low-copy-number copia-type retroelement in Medicago truncatula active during tissue culture, Plant Physiology, vol.151, pp.1250-1263, 2009.

M. Ramirez, M. A. Graham, L. Blanco-lopez, S. Silvente, A. Medrano-soto et al., Sequencing and analysis of common bean ESTs. Building a foundation for functional genomics, Plant Physiology, vol.137, pp.1211-1227, 2005.

M. Redondo-nieto, L. Pulido, M. Reguera, I. Bonilla, and L. Bolanos, Developmentally regulated membrane glycoproteins sharing antigenicity with rhamnogalacturonan II are not detected in nodulated boron deficient Pisum sativum, Plant, Cell & Environment, vol.30, pp.1436-1443, 2007.

C. Rosenberg, P. Boistard, J. Denarie, and F. Casse-delbart, Genes controlling early and late functions in symbiosis are located on a megaplasmid in Rhizobium meliloti, Molecular General Genetics, vol.184, pp.326-333, 1981.

D. A. Samac, S. Penuela, J. A. Schnurr, E. N. Hunt, D. Foster-hartnett et al., Expression of coordinately regulated defence response genes and analysis of their role in disease resistance in Medicago truncatula, Molecular Plant Pathology, vol.12, pp.786-798, 2011.

M. Scholte, I. Erfurth, S. Rippa, S. Mondy, V. Cosson et al., T-DNA tagging in the model legume Medicago truncatula allows efficient gene discovery, Molecular Breeding, vol.10, pp.203-215, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00147040

C. G. Starker, A. L. Parra-colmenares, L. Smith, R. M. Mitra, and S. R. Long, Nitrogen fixation mutants of Medicago truncatula fail to support plant and bacterial symbiotic gene expression, Plant Physiology, vol.140, pp.671-680, 2006.

N. Suganuma, A. Yamamoto, A. Itou, T. Hakoyama, M. Banba et al., cDNA macroarray analysis of gene expression in ineffective nodules induced on the Lotus japonicus sen1 mutant, Molecular Plant-Microbe Interactions, vol.17, pp.1223-1233, 2004.

M. Tadege, J. Wen, J. He, H. Tu, Y. Kwak et al., Large-scale insertional mutagenesis using the Tnt1 retrotransposon in the model legume Medicago truncatula, Plant Journal, vol.54, pp.335-347, 2008.

A. C. Timmers, M. C. Auriac, and G. Truchet, Refined analysis of early symbiotic steps of the Rhizobium-Medicago interaction in relationship with microtubular cytoskeleton rearrangements, Development, vol.126, pp.3617-3628, 1999.

A. C. Timmers, E. Soupene, M. C. Auriac, F. De-billy, J. Vasse et al., Saprophytic intracellular rhizobia in alfalfa nodules, Molecular Plant-Microbe Interactions, vol.13, pp.1204-1213, 2000.

W. Van-de-velde, J. C. Guerra, D. Keyser, A. De-rycke, R. Rombauts et al., Aging in legume symbiosis. A molecular view on nodule senescence in Medicago truncatula, Plant Physiology, vol.141, pp.711-720, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00118573

W. Van-de-velde, G. Zehirov, A. Szatmari, M. Debreczeny, H. Ishihara et al., Plant peptides govern terminal differentiation of bacteria in symbiosis, Science, vol.327, pp.1122-1126, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00856104

J. Vasse, F. De-billy, S. Camut, and G. Truchet, Correlation between ultrastructural differentiation of bacteroids and nitrogen fixation in alfalfa nodules, Journal of Bacteriology, vol.172, pp.4295-4306, 1990.

J. Vasse, F. De-billy, and G. Truchet, Abortion of infection during the Rhizobium meliloti-alfalfa symbiotic interaction is accompanied by a hypersensitive reaction, The Plant Journal, vol.4, pp.555-566, 1993.
URL : https://hal.archives-ouvertes.fr/hal-02715739

J. M. Vinardell, E. Fedorova, A. Cebolla, Z. Kevei, G. Horvath et al., Endoreduplication mediated by the anaphase-promoting complex activator ccs52a is required for symbiotic cell differentiation in Medicago truncatula nodules, Plant Cell, vol.15, pp.2093-2105, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00134591

D. Wang, J. Griffitts, C. Starker, E. Fedorova, E. Limpens et al., A nodule-specific protein secretory pathway required for nitrogen-fixing symbiosis, Science, vol.327, pp.1126-1129, 2010.