Modulation of mTORC1 Signaling Pathway by HIV-1

Burkitkan Akbay , Anna Shmakova , Yegor Vassetzky (1, 2, 3) , Svetlana Dokudovskaya (4, 2, 3)

1 METSY - Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques
2 IGR - Institut Gustave Roussy
3 UMR8126 - Signalisation, noyaux et innovations en cancérologie
4 IJM (UMR_7592) - Institut Jacques Monod

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to dierent stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication

Keywords: HIV-1; HIV-1 related diseases; mTORC1 pathway; autophagy

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Cancer

Burkitkan Akbay, Anna Shmakova, Yegor Vassetzky, Svetlana Dokudovskaya. Modulation of mTORC1 Signaling Pathway by HIV-1. Cells, 2020, 9 (5), pp.1090. ⟨10.3390/cells9051090⟩. ⟨hal-02870188⟩