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Modulation of mTORC1 Signaling Pathway by HIV-1
Abstract : Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to di erent stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication
Cited literature [140 references]
https://hal-cnrs.archives-ouvertes.fr/hal-02870188
Contributor : Colette Orange <>
Submitted on : Wednesday, August 26, 2020 - 3:25:02 PM
Last modification on : Saturday, July 3, 2021 - 12:29:07 AM
Long-term archiving on: : Friday, November 27, 2020 - 12:54:42 PM
Contributor : Colette Orange <>
Submitted on : Wednesday, August 26, 2020 - 3:25:02 PM
Last modification on : Saturday, July 3, 2021 - 12:29:07 AM
Long-term archiving on: : Friday, November 27, 2020 - 12:54:42 PM
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cells-09-01090.pdf
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