Modulation of mTORC1 Signaling Pathway by HIV-1 - Archive ouverte HAL Access content directly
Journal Articles Cells Year : 2020

Modulation of mTORC1 Signaling Pathway by HIV-1

, , (1, 2, 3) , (4, 2, 3)
1
2
3
4

Abstract

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to di erent stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication
Fichier principal
Vignette du fichier
cells-09-01090.pdf (1.33 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02870188 , version 1 (26-08-2020)

Identifiers

Cite

Burkitkan Akbay, Anna Shmakova, Yegor Vassetzky, Svetlana Dokudovskaya. Modulation of mTORC1 Signaling Pathway by HIV-1. Cells, 2020, 9 (5), pp.1090. ⟨10.3390/cells9051090⟩. ⟨hal-02870188⟩
75 View
35 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More