Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders

Karin Schad (1) , Katrin Baumann Conzett , Marie Zipser , Valérie Enderlin (2) , Jivko Kamarashev , Lars French , Reinhard Dummer (3, 1)

1 University Hospital Zurich, Department of Dermatology
2 Unité sous contrat nutrition et signalisation cellulaire
3 University hospital of Zurich [Zurich]

Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling pathway is constitutively activated in melanoma. AZD6244 blocks MEK1/2, inhibiting ERK phosphorylation. We focus on associated cutaneous toxicity and we attempt to understand the underlying pathophysiology and design treatment strategies.

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Psychology and behavior; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Cognitive Sciences

Karin Schad, Katrin Baumann Conzett, Marie Zipser, Valérie Enderlin, Jivko Kamarashev, et al.. Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders. Clinical Cancer Research, 2010, 16 (3), pp.1058-1064. ⟨10.1158/1078-0432.CCR-09-1766⟩. ⟨hal-02526751⟩