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Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders

Karin Schad 1 Katrin Baumann Conzett Marie Zipser Valérie Enderlin 2 Jivko Kamarashev Lars French Reinhard Dummer 3, 1
1 University Hospital Zurich, Department of Dermatology
2 Unité sous contrat nutrition et signalisation cellulaire
3 University hospital of Zurich [Zurich]
Abstract : Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling pathway is constitutively activated in melanoma. AZD6244 blocks MEK1/2, inhibiting ERK phosphorylation. We focus on associated cutaneous toxicity and we attempt to understand the underlying pathophysiology and design treatment strategies.
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https://hal-cnrs.archives-ouvertes.fr/hal-02526751
Contributor : Alain Perignon <>
Submitted on : Tuesday, March 31, 2020 - 5:34:54 PM
Last modification on : Thursday, April 2, 2020 - 1:52:52 AM

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Karin Schad, Katrin Baumann Conzett, Marie Zipser, Valérie Enderlin, Jivko Kamarashev, et al.. Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders. Clinical Cancer Research, American Association for Cancer Research, 2010, 16 (3), pp.1058-1064. ⟨10.1158/1078-0432.CCR-09-1766⟩. ⟨hal-02526751⟩

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