Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders - Archive ouverte HAL Access content directly
Journal Articles Clinical Cancer Research Year : 2010

Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders

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Abstract

Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling pathway is constitutively activated in melanoma. AZD6244 blocks MEK1/2, inhibiting ERK phosphorylation. We focus on associated cutaneous toxicity and we attempt to understand the underlying pathophysiology and design treatment strategies.
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hal-02526751 , version 1 (31-03-2020)

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Karin Schad, Katrin Baumann Conzett, Marie Zipser, Valérie Enderlin, Jivko Kamarashev, et al.. Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders. Clinical Cancer Research, 2010, 16 (3), pp.1058-1064. ⟨10.1158/1078-0432.CCR-09-1766⟩. ⟨hal-02526751⟩

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