Epidemiology of dementia: the burden on society, the challenges for research, Methods Mol. Biol, vol.1750, pp.3-14, 2018. ,
Alzheimer's disease, N. Engl. J. Med, vol.362, pp.329-344, 2010. ,
Amyloid-beta and tau complexitytowards improved biomarkers and targeted therapies, Nat. Rev. Neurol, vol.14, pp.22-39, 2018. ,
Alzheimer's disease: the amyloid cascade hypothesis, Science, vol.256, pp.184-185, 1992. ,
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers, Lancet Neurol, vol.12, pp.207-216, 2013. ,
Understanding the cause of sporadic Alzheimer's disease, Expert Rev. Neurother, vol.14, pp.621-630, 2014. ,
Trial of solanezumab for mild dementia due to Alzheimer's disease, N. Engl. J. Med, vol.378, pp.321-330, 2018. ,
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease, N. Engl. J. Med, vol.370, pp.322-333, 2014. ,
A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease, Alzheimers Res. Ther, vol.9, p.95, 2017. ,
Addendum: The antibody aducanumab reduces Abeta plaques in Alzheimer's disease, Nature, vol.546, p.564, 2017. ,
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, vol.34, pp.939-944, 1984. ,
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimers Dement, vol.7, pp.263-269, 2011. ,
NIA-AA Research Framework: toward a biological definition of Alzheimer's disease, Alzheimers Dement, vol.14, pp.535-562, 2018. ,
Neuroscience: Glia -more than just brain glue, Nature, vol.457, pp.675-677, 2009. ,
Glial cells and their function in the adult brain: a journey through the history of their ablation, Front. Cell. Neurosci, vol.11, p.24, 2017. ,
Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging, J. Neuroinflammation, vol.11, p.120, 2014. ,
Physiology of astroglia, Physiol. Rev, vol.98, pp.239-389, 2018. ,
Signaling at the gliovascular interface, J. Neurosci, vol.23, pp.9254-9262, 2003. ,
The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease, Neuron, vol.96, pp.17-42, 2017. ,
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation, Fluids Barriers CNS, vol.9, p.23, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00772323
Sweet sixteen for ANLS, J. Cereb. Blood Flow Metab, vol.32, pp.1152-1166, 2012. ,
Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior, Annu. Rev. Physiol, vol.72, pp.335-355, 2010. ,
Neuronal vs glial glutamate uptake: resolving the conundrum, Neurochem. Int, vol.98, pp.29-45, 2016. ,
Glutamate transporters: diversity, function, and involvement in neurologic disease, Neurology, vol.74, pp.259-264, 2010. ,
Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.17513-17518, 2006. ,
Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.6361-6366, 1996. ,
Vimentin regulates peripheral nerve myelination, Development, vol.139, pp.1359-1367, 2012. ,
Monoamine oxidase-B in astrocytes, Glia, vol.8, pp.122-132, 1993. ,
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders, Brain, vol.140, pp.2460-2474, 2017. ,
Structures and mechanism of the monoamine oxidase family, Biomol. Concepts, vol.2, pp.365-377, 2011. ,
A phenotypic change but not proliferation underlies glial responses in Alzheimer disease, Am. J. Pathol, vol.182, pp.2332-2344, 2013. ,
Alois Alzheimer: a hundred years after the discovery of the eponymous disorder, Int. J. Biomed. Sci, vol.2, pp.196-204, 2006. ,
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease, Am. J. Pathol, vol.179, pp.1373-1384, 2011. ,
)H-deprenyl and (3)H-PIB autoradiography show different laminar distributions of astroglia and fibrillar beta-amyloid in Alzheimer brain, J. Neuroinflammation, vol.10, issue.3, p.90, 2013. ,
Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised by, 2017. ,
Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ, J. Biol. Chem, vol.281, pp.24566-24574, 2006. ,
Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism, J. Neurosci, vol.26, pp.10939-10948, 2006. ,
Clearance systems in the brain-implications for Alzheimer disease, Nat. Rev. Neurol, vol.11, pp.457-470, 2015. ,
Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice, J. Biol. Chem, vol.278, pp.18408-18418, 2003. ,
Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease, Dement. Geriatr. Cogn. Disord, vol.19, pp.171-183, 2005. ,
Region-specific loss of glutamate innervation in Alzheimer's disease, Neurosci. Lett, vol.73, pp.77-80, 1987. ,
Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease, J. Neurosci. Res, vol.55, pp.218-229, 1999. ,
Glutamate transporter GLT1 expression in Alzheimer disease and dementia with Lewy bodies, Front. Aging Neurosci, vol.10, p.122, 2018. ,
Astrocyte function is modified by Alzheimer's disease-like pathology in aged mice, J. Alzheimers Dis, vol.18, pp.177-189, 2009. ,
Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice, Exp. Neurol, vol.163, pp.381-387, 2000. ,
Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients, J. Neurochem, vol.80, pp.807-814, 2002. ,
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate, Neuron, vol.16, pp.675-686, 1996. ,
GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model, J. Alzheimers Dis, vol.26, pp.447-455, 2011. ,
Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Abeta plaques by iGluSnFR two-photon imaging, Nat. Commun, vol.7, p.13441, 2016. ,
Astrocytic glutamatergic transporters are involved in Abeta-induced synaptic dysfunction, Brain Res, vol.1678, pp.129-137, 2018. ,
Characterizing Alzheimer's disease using a hypometabolic convergence index, Neuroimage, vol.56, pp.52-60, 2011. ,
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.10625-10629, 1994. ,
Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle, Dev. Neurosci, vol.20, pp.291-299, 1998. ,
Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex, Neuron, vol.37, pp.275-286, 2003. ,
18)F]FDG PET signal is driven by astroglial glutamate transport, Nat. Neurosci, vol.20, pp.393-395, 2017. ,
Amyloid beta 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks, J. Cereb. Blood Flow Metab, vol.35, pp.1348-1357, 2015. ,
Supply and demand in cerebral energy metabolism: the role of nutrient transporters, J. Cereb. Blood Flow Metab, vol.27, pp.1766-1791, 2007. ,
Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease, Ann. Neurol, vol.35, pp.546-551, 1994. ,
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease, FEBS Lett, vol.582, pp.359-364, 2008. ,
Fast and reversible stimulation of astrocytic glycolysis by K + and a delayed and persistent effect of glutamate, J. Neurosci, vol.31, pp.4709-4713, 2011. ,
NBCe1 mediates the acute stimulation of astrocytic glycolysis by extracellular K +, J. Neurosci, vol.31, pp.14264-14271, 2011. ,
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue, J. Cereb. Blood Flow Metab, 2017. ,
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex, J. Neurosci, vol.34, pp.11929-11947, 2014. ,
Na/HCO 3 cotransporters in rat brain: expression in glia, neurons, and choroid plexus, J. Neurosci, vol.20, pp.6839-6848, 2000. ,
Channel-mediated lactate release by K(+)-stimulated astrocytes, J. Neurosci, vol.35, pp.4168-4178, 2015. ,
Hemichannel-mediated release of lactate, J. Cereb. Blood Flow Metab, vol.36, pp.1202-1211, 2016. ,
Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes, J. Neurochem, vol.63, pp.910-916, 1994. ,
Expression of glucose transporter GLUT3 by endotoxin in cultured rat astrocytes: the role of nitric oxide, J. Neurochem, vol.79, pp.17-24, 2001. ,
Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism, J. Biol. Chem, vol.292, pp.9432-9438, 2017. ,
Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1alpha-mediated target gene activation, J. Neurosci, vol.32, pp.9727-9735, 2012. ,
Neuronal nitric oxide synthase (nNOS) mRNA expression and NADPH-diaphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer's disease brains, Brain Res. Mol. Brain Res, vol.41, pp.36-49, 1996. ,
Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer's disease: involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser(293), Neurochem. Int, vol.99, pp.52-61, 2016. ,
Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimer's disease, Neurodegener. Dis, vol.7, pp.251-259, 2010. ,
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase, J. Exp. Med, vol.202, pp.1163-1169, 2005. ,
NH 4 + triggers the release of astrocytic lactate via mitochondrial pyruvate shunting, Proc. Natl. Acad. Sci. U. S. A, vol.112, pp.11090-11095, 2015. ,
Astrocyte-neuron lactate transport is required for long-term memory formation, Cell, vol.144, pp.810-823, 2011. ,
Physiologic coupling of glial glycogen metabolism to neuronal activity in brain. Can, J. Physiol. Pharmacol, vol.70, pp.138-144, 1992. ,
Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex, J. Neurosci, vol.30, pp.15298-15303, 2010. ,
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration, Nat. Neurosci, vol.18, pp.521-530, 2015. ,
Fluid markers of traumatic brain injury, Mol. Cell. Neurosci, vol.66, pp.99-102, 2015. ,
The serum concentration of the calcium binding protein S100B is positively associated with cognitive performance in older adults, Front. Aging Neurosci, vol.5, p.61, 2013. ,
Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer's disease and vascular dementia, J. Neuroimmunol, vol.57, pp.165-170, 1995. ,
Serum levels of S100B and NSE proteins in Alzheimer's disease patients, J. Neuroinflammation, vol.7, p.6, 2010. ,
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease, Nat. Rev. Neurol, vol.6, pp.131-144, 2010. ,
Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration, J. Neurochem, vol.136, pp.258-261, 2016. ,
The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia, Eur. Neurol, vol.46, pp.35-38, 2001. ,
Neuron-specific enolase, S-100 protein, myelin basic protein and lactate in CSF in dementia, Dement. Geriatr. Cogn. Disord, vol.8, pp.169-173, 1997. ,
Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease, J. Alzheimers Dis, vol.17, pp.541-551, 2009. ,
Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease, Neurochem. Int, vol.39, pp.409-413, 2001. ,
CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis, Lancet Neurol, vol.15, pp.673-684, 2016. ,
D-Serine levels in Alzheimer's disease: implications for novel biomarker development, Transl. Psychiatry, vol.5, p.561, 2015. ,
YKL-40 (chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies, J. Neuroinflammation, vol.14, p.118, 2017. ,
YKL-40 -an emerging biomarker in cardiovascular disease and diabetes. Cardiovasc, Diabetol, vol.8, p.61, 2009. ,
Relationship between beta-secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's disease, J. Alzheimers Dis, vol.42, pp.157-167, 2014. ,
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease, Biol. Psychiatry, vol.68, pp.903-912, 2010. ,
Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease, Neurology, vol.85, pp.626-633, 2015. ,
Cerebrospinal fluid level of YKL-40 protein in preclinical and prodromal Alzheimer's disease, J. Alzheimers Dis, vol.42, pp.901-908, 2014. ,
In vivo imaging of glial activation in Alzheimer's disease, Front. Neurol, vol.9, p.625, 2018. ,
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain, Neuropathol. Appl. Neurobiol, vol.35, pp.306-328, 2009. ,
Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging, J. Neurosci, vol.32, pp.10809-10818, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-02110993
Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon, p.11, 1995. ,
, L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping, J. Nucl. Med, vol.36, pp.1255-1262
Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, Synapse, vol.99008, issue.2, pp.542-551, 2012. ,
Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease, Eur. J. Nucl. Med. Mol. Imaging, vol.30, pp.85-95, 2003. ,
Evidence for astrocytosis in ALS demonstrated by [11]C(L)-deprenyl-D2 PET, J. Neurol. Sci, vol.255, pp.17-22, 2007. ,
PET with 11 C-deuterium-deprenyl and 18 F-FDG in focal epilepsy, Acta Neurol. Scand, vol.103, pp.360-366, 2001. ,
Astroglial responses to amyloid-beta progression in a mouse model of Alzheimer's disease, Mol. Imaging Biol, vol.20, pp.605-614, 2018. ,
Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study, Eur. J. Nucl. Med. Mol. Imaging, vol.42, pp.1119-1132, 2015. ,
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11 C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11 C-Pittsburgh compound B and 18 F-FDG, J. Nucl. Med, vol.53, pp.37-46, 2012. ,
Early astrocytosis in autosomal dominant Alzheimer's disease measured in vivo by multi-tracer positron emission tomography, Sci. Rep, vol.5, p.16404, 2015. ,
Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease, Brain, vol.139, pp.922-936, 2016. ,
Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain, J. Nucl. Med, vol.55, pp.838-844, 2014. ,
Evaluation of (11)C-BU99008, a positron emission tomography ligand for the imidazoline2 binding site in human brain, J. Nucl. Med, vol.59, pp.1597-1602, 2018. ,
Probing astrocyte metabolism in vivo: proton magnetic resonance spectroscopy in the injured and aging brain, Front. Aging Neurosci, vol.7, p.202, 2015. ,
Various MRS application tools for Alzheimer disease and mild cognitive impairment, AJNR Am. J. Neuroradiol, vol.35, pp.4-11, 2014. ,
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer's disease, Neuroreport, vol.13, pp.183-186, 2002. ,
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T, AJNR Am. J. Neuroradiol, vol.24, pp.843-849, 2003. ,
Early Alzheimer's disease neuropathology detected by proton MR spectroscopy, J. Neurosci, vol.34, pp.16247-16255, 2014. ,
Apolipoprotein E isoforms differentially regulate Alzheimer's disease and amyloid-beta-induced inflammatory response in vivo and in vitro, J. Alzheimers Dis, vol.57, pp.1265-1279, 2017. ,
Impaired autophagy in APOE4 astrocytes, J. Alzheimers Dis, vol.51, pp.915-927, 2016. ,
APOE epsilon4/epsilon4 diminishes neurotrophic function of human iPSC-derived astrocytes, Hum. Mol. Genet, vol.26, pp.2690-2700, 2017. ,
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides, Nat. Med, vol.10, pp.719-726, 2004. ,
APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types, Neuron, vol.98, p.1294, 2018. ,
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease, Glia, vol.58, pp.300-314, 2010. ,
Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease, Neurobiol. Aging, vol.35, pp.492-510, 2014. ,
Vimentin immunoreactivity in normal and pathological human brain tissue, Acta Neuropathol, vol.84, pp.157-162, 1992. ,
S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions, Biochim. Biophys. Acta, vol.1223, pp.398-403, 1994. ,
Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease, Glia, vol.58, pp.831-838, 2010. ,
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease, ASN Neuro, vol.3, pp.271-279, 2011. ,
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease, Glia, vol.66, pp.637-653, 2018. ,
Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex, Brain Res, vol.463, pp.357-361, 1988. ,
Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease, Medicina (B Aires), vol.112, pp.213-218, 1991. ,
Astrocytic adenosine A2A receptors control the amyloid-beta peptide-induced decrease of glutamate uptake, J. Alzheimers Dis, vol.31, pp.555-567, 2012. ,
beta-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors, Glia, vol.61, pp.1673-1686, 2013. ,
Abeta pathology downregulates brain mGluR5 density in a mouse model of Alzheimer, Neuropharmacology, vol.133, pp.512-517, 2018. ,
Abeta induces astrocytic glutamate release extrasynaptic NMDA receptor activation, and synaptic loss, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.2518-2527, 2013. ,
Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain, Neurobiol. Aging, vol.31, pp.578-590, 2010. ,
Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB, Glia, vol.61, pp.1134-1145, 2013. ,
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice, Neurobiol. Aging, vol.34, pp.2341-2351, 2013. ,
Tonic inhibition in dentate gyrus impairs longterm potentiation and memory in an Alzheimer's [corrected] disease model, Nat. Commun, vol.5, p.4159, 2014. ,
Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes, Glia, vol.41, pp.207-211, 2003. ,
High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques, Exp. Neurol, vol.192, pp.215-225, 2005. ,
Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology, J. Neurol. Sci, vol.225, pp.39-49, 2004. ,
Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice, Brain Res, vol.1181, pp.93-103, 2007. ,
The contribution of activated astrocytes to Abeta production: implications for Alzheimer's disease pathogenesis, J. Neuroinflammation, vol.8, p.150, 2011. ,
Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulusdependent, Glia, vol.41, pp.169-179, 2003. ,
Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology, J. Neuropathol. Exp. Neurol, vol.65, pp.976-987, 2006. ,
Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR, Neuron, vol.4, pp.253-267, 1990. ,
Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme, J. Neurochem, vol.92, pp.226-234, 2005. ,
Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease, Neurobiol. Aging, vol.31, pp.1743-1757, 2010. ,
Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity, J. Neuropathol. Exp. Neurol, vol.68, pp.902-914, 2009. ,
Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture, Cell Death Dis, vol.2, p.167, 2011. ,
Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells, Proc. Natl. Acad. Sci. U. S. A, vol.92, pp.10738-10741, 1995. ,
Expression of interleukin-18 is increased in the brains of Alzheimer'sdiseasepatients, Neurobiol. Aging, vol.30, pp.198-209, 2009. ,
High resolution dissection of reactive glial nets in Alzheimer's disease, Sci. Rep, vol.6, p.24544, 2016. ,
Astrocyte transforming growth factor beta 1 protects synapses against Abeta oligomers in Alzheimer's disease model, J. Neurosci, vol.37, pp.6797-6809, 2017. ,
Dual pathways mediate beta-amyloid stimulated glutathione release from astrocytes, Glia, vol.63, pp.2208-2219, 2015. ,
Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity, J. Neurosci, vol.23, pp.5088-5095, 2003. ,
Effects of Bambusae concretio Salicea (Chunchukhwang) on amyloid beta-induced cell toxicity and antioxidative enzymes in cultured rat neuronal astrocytes, J. Ethnopharmacol, vol.98, pp.259-266, 2005. ,
Heme oxygenase-1 derived carbon monoxide suppresses Abeta1-42 toxicity in astrocytes, Cell Death Dis, vol.8, p.2884, 2017. ,
212-2, agonist of cannabinoid receptors, prevents amyloid beta1-42 effects on astrocytes in primary culture, PLoS One, vol.55, p.122843, 2015. ,
Advanced glycation endproducts colocalize with inducible nitric oxide synthase in Alzheimer's disease, Brain Res, vol.920, pp.32-40, 2001. ,
Ca(2+)-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid beta-treated astrocytes and in a model of Alzheimer's disease, Aging Cell, vol.12, pp.292-302, 2013. ,
Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease, Neuroscience, vol.159, pp.1055-1069, 2009. ,