, GBD 2015 Chronic RespiratoryD isease Collaborators, vol.5, pp.691-706, 2017.

K. Najima, J. C. Owers, B. Ashe, and M. Zimmerman, J. Biol. Chem, vol.254, pp.4027-14032, 1979.

H. J. Halpern, Vivo EPR (ESR): Theory and Application, pp.201-232, 2003.

K. Matsumoto, S. Subramanian, R. Murugesan, J. B. Mitchell, and M. C. Krishna, Antioxid. RedoxS ignaling, vol.9, pp.125-1141, 2007.

E. Te-rreno, D. D. Castelli, A. Viale, and S. Aime, Chem. Rev, vol.12, pp.19-3042, 2010.

D. J. Lurie, I. Nicholson, and J. R. Mallard, J. Magn.R eson, vol.95, pp.5-409, 1991.

S. Matsumoto, H. Yasui, S. Batra, Y. Kinoshita, M. Bernardo et al., Proc. Natl. Acad. Sci, vol.106, pp.1-7898, 2009.

J. Weaver, S. R. Urks, K. J. Liu, J. P. Kao, and G. M. Rosen, J. Magn. Reson, vol.271, pp.68-74, 2016.

B. Epel, S. V. Sundramoorthy, M. Rzykawska-serda, M. C. Maggio, M. Ts-eytlin et al., J. Magn. Reson, vol.276, pp.31-36, 2017.

T. Kawano, M. Murata, F. Hyodo, H. Eto, N. Kosem et al., Sci. Rep, vol.6, p.32604, 2016.

I. Dhimitruka, A. A. Bobko, T. D. Eubank, D. A. Komarov, and V. V. Khramtsov, J. Am. Chem. Soc, vol.135, pp.904-5910, 2013.

J. Cløment, S. Barbati, C. Frejaville, A. Rockenbauer, and P. Ordo, J. Chem. Soc. Perkin Trans, vol.2, pp.1471-1475, 2001.

W. Takahashi, A. A. Obko, I. Dhimitruka, H. Hirata, J. L. Zweier et al., Appl. Magn.R eson, vol.45, pp.817-826, 2014.

S. Thøtiot-laurent, G. Osset, J. Cløment, M. Cassien, A. Mercier et al., , vol.18, pp.300-315, 2017.

G. Audran, L. Bosco, P. Brømond, T. Butscher, and S. R. , Org. Biomol.C hem, vol.1, pp.288-1292, 2016.

S. M. Hacker, C. Intze, A. Marx, M. Drescher, and C. Ommun, , pp.7262-7264, 2014.

E. Parzy, V. Ouchaud, P. Massot, P. Voisin, N. Koonjoo et al., PLoS One, issue.8, p.57946, 2013.

N. Koonjoo, E. Arzy, P. Assot, M. Lepetit-coiffe, S. R. Marque et al., Contrast Media Mol. Imaging, vol.9, pp.363-371, 2014.

G. Audran, L. Osco, P. Bremond, J. Franconi, N. Koonjoo et al., Angew.C hem.I nt, vol.54, pp.13379-13384, 2015.

. Angew and . Chem, , vol.127, pp.13577-13582, 2015.

E. G. Delmar, C. Argman, J. W. Brodrick, and M. C. Eokas, Anal.B iochem, vol.99, pp.316-320, 1979.

, 100 8C( seer ef. [23]), ammonium acetate (see ref. [24])a lso failed to improve the yield of the reaction as well as the two-stepp rocedure basedo nt he generation of imine followedb ya dditiono fdiethyl phosphite (see ref, Otherc onditionss ucha sM g

S. Bhagat, A. K. Chakraborti, and J. , Org.C hem, vol.72, pp.1-263, 2007.

E. Moreno-pineda, F. Tuna, R. G. Pritchard, A. C. Regan, R. E. Winpenny et al., Chem. Commun, vol.49, pp.3522-3524, 2013.

Y. Li, M. -y.y-e,-r.-z.h-uang, G. Ao, Y. Pan, Z. Liao et al., Med. Chem. Res, vol.23, pp.3-144, 2014.

E. D. Matveeva, T. A. Podrugina, E. V. Tishkovskaya, L. G. To-milova, and N. S. Zefirov, Synlett, vol.2, pp.321-2324, 2003.

J. Wu, W. Sun, W. Wang, and H. Xia, Chin. J. Chem, vol.24, pp.54-1057, 2006.

P. Brømond, A. Koïta, S. R. Marque, V. Pesce, V. Roubaud et al., Org. Lett, vol.14, pp.358-361, 2012.

C. Bçhm, W. F. Austin, and D. Trauner, Tetrahedron:A symmetry, vol.14, pp.7-8, 2003.

, CCDC: 1539640 and 1539639 for 5a and 5b,r espectively

M. Hollenstein, Chem. Eur.J, vol.18, pp.3320-13330, 2012.

K. Yoshida, K. Amaguchi, T. One, Y. Unno, A. Asai et al., Org. Lett, vol.10, pp.571-3574, 2008.

C. D. Chang, M. Waki, M. Ahmad, J. Meienhofer, E. O. et al., Int. J. Pept. Protein Res, vol.1, pp.59-66, 1980.

N. D. Rawlings, M. Aller, A. J. Arrett, and A. Bateman, Nucleic Acids Res, vol.42, pp.503-509, 2014.

I. Schechter and A. Erger, Biochem. Biophys. Res.C ommun, vol.27, pp.1-57, 1967.

, Version of record online, 2018.

, Chem. Eur.J, vol.24, pp.7615-7619, 2018.

. Wiley-vch-verlag-gmbh-&co and . Kgaa,