Skip to Main content Skip to Navigation
Journal articles

Extracellular vesicles for personalized medicine: the input of physically triggered production, loading and theranostic properties

Abstract : Emerging advances in extracellular vesicle (EV) research brings along new promises for tailoring clinical treatments in order to meet specific disease features of each patient in a personalized medicine concept. EVs may act as regenerative effectors conveying endogenous therapeutic factors from parent cells or constitute a bio-camouflaged delivery system for exogenous therapeutic agents. Physical stimulation may be an important tool in the field of EVs for personalized therapy by powering EV production, loading and therapeutic properties. Physically-triggered EV production is inspired by naturally occurring EV release by shear stress in blood vessels. Bioinspired physically-triggered EV production technologies may bring along high yield advantages combined to scalability assets. Physical stimulation may also provide new prospects for high-efficient EV loading. Additionally, physically-triggered EV theranostic properties brings new hopes for spatio-temporal controlled therapy combined to tracking. Technological considerations related to EV-based personalized medicine and the input of physical stimulation on EV production, loading and theranostic properties will be overviewed herein.
Complete list of metadatas

Cited literature [185 references]  Display  Hide  Download

https://hal-cnrs.archives-ouvertes.fr/hal-02408369
Contributor : Amanda Silva <>
Submitted on : Friday, December 13, 2019 - 6:46:02 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:39 AM
Long-term archiving on: : Saturday, March 14, 2020 - 1:28:50 PM

File

Piffoux Review revised version...
Files produced by the author(s)

Identifiers

Collections

Citation

Max Piffoux, Alba Nicolás-Boluda, Vladmir Mulens-Arias, Sophie Richard, Gabriel Rahmi, et al.. Extracellular vesicles for personalized medicine: the input of physically triggered production, loading and theranostic properties. Advanced Drug Delivery Reviews, Elsevier, 2019, 138, pp.247-258. ⟨10.1016/j.addr.2018.12.009⟩. ⟨hal-02408369⟩

Share

Metrics

Record views

280

Files downloads

830