Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes

Amandine Pelletier (1) , Olivier Périot (2) , Bixente Dilharreguy , Bassem Hiba (3) , Martine Bordessoules , Sandra Chanraud , Karine Pérès (4) , Hélène Amieva (5) , Jean-François Dartigues (6) , Michèle Allard (2) , Gwenaelle Catheline (2)

1 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
2 INCIA - Institut de Neurosciences cognitives et intégratives d'Aquitaine
3 CRMSB - Centre de résonance magnétique des systèmes biologiques
4 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement
5 Prévention et prise en charge des traumatismes [Bordeaux]
6 Epidémiologie et Biostatistique [Bordeaux]

Microstructural changes of White Matter (WM) associated with aging have been widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel, White Matter Hyperintensities (WMH) as observed on a T2-weighted MRI are extremely common in older individuals. However, few studies have investigated both phenomena conjointly. The present study investigates aging effects on DTI parameters in absence and in presence of WMH. Diffusion maps were constructed based on 21 directions DTI scans of young adults (n = 19, mean age = 33 SD = 7.4) and two age-matched groups of older adults, one presenting low-level-WMH (n = 20, mean age = 78, SD = 3.2) and one presenting high-level-WMH (n = 20, mean age = 79, SD = 5.4). Older subjects with low-level-WMH presented modifications of DTI parameters in comparison to younger subjects, fitting with the DTI pattern classically described in aging, i.e., Fractional Anisotropy (FA) decrease/Radial Diffusivity (RD) increase. Furthermore, older subjects with high-level-WMH showed higher DTI modifications in Normal Appearing White Matter (NAWM) in comparison to those with low-level-WMH. Finally, in older subjects with high-level-WMH, FA, and RD values of NAWM were associated with to WMH burden. Therefore, our findings suggest that DTI modifications and the presence of WMH would be two interdependent processes but occurring within different temporal windows. DTI changes would reflect the early phase of white matter changes and WMH would appear as a consequence of those changes.

Mots clés: white matter hyperintensities; diffusion tensor imaging; aging; normal appearing white matter

Domaines: Sciences du Vivant [q-bio]

Amandine Pelletier, Olivier Périot, Bixente Dilharreguy, Bassem Hiba, Martine Bordessoules, et al.. Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes. Frontiers in Aging Neuroscience, 2016, 7, ⟨10.3389/fnagi.2015.00255⟩. ⟨hal-02404742⟩