H. L. Roderick and S. J. Cook, Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival, Nature Rev. Cancer, vol.8, pp.361-375, 2008.

N. Prevarskaya, H. Ouadid-ahidouch, R. Skryma, and Y. Shuba, Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?, Phil. Trans. R. Soc. B, vol.369, p.20130097, 2014.

N. Prevarskaya, R. Skryma, and Y. Shuba, Calcium in tumour metastasis: new roles for known actors, Nature Rev. Cancer, vol.11, pp.609-618, 2011.

, Scientific RepoRts |, vol.6, p.39449

A. Panner and R. D. Wurster, T-type calcium channels and tumor proliferation, Cell Calcium, vol.40, pp.253-259, 2006.

I. Aoki, Y. J. Lin-wu, A. C. Silva, R. M. Lynch, and A. P. Koretsky, In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI, NeuroImage, vol.22, pp.1046-1059, 2004.

B. Grünecker, Fractionated manganese injections: effects on MRI contrast enhancement and physiological measures in C57BL/6 mice, NMR Biomed, vol.23, pp.913-921, 2010.

T. Inoue, T. Majid, and R. G. Pautler, Manganese enhanced MRI (MEMRI): neurophysiological applications, Rev. Neurosci, vol.22, issue.6, pp.675-694, 2011.

S. J. Jackson, Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl2: Hippocampal signal enhancement without disruption of hippocampus-dependent behavior, Behavioural Brain Res, vol.216, pp.293-300, 2011.

H. Lee, J. Silva, A. C. Merkle, H. Koretsky, and A. P. , Manganese-enhanced Magnetic Resonance Imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast, Magn. Reson. Med, vol.53, pp.640-648, 2005.

A. C. Silva, H. Lee, J. Aoki, I. Koretsky, and A. P. , Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations, NMR Biomed, vol.17, pp.532-543, 2004.

T. Watanabe, O. Natt, S. Boretius, J. Frahm, and T. Michaelis, In Vivo 3D MRI staining of mouse brain after subcutaneous application of MnCl2, Magn. Reson. Med, vol.48, pp.852-859, 2002.

X. Yu, Y. Z. Wadghiri, D. H. Sanes, and D. H. Turnbull, In vivo auditory brain mapping in mice with Mn-enhanced MRI, Nat. Neuroscience, vol.8, pp.961-968, 2005.

C. R. Castets, Fast and robust 3D T1 mapping using spiral encoding and steady RF excitation at 7T: application to cardiac manganese enhanced MRI (MEMRI) in mice, NMR Biomed, vol.28, issue.7, pp.881-889, 2015.

B. Waghorn, Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganeseenhanced MRI in a murine myocardial infarction model, NMR Biomed, vol.21, pp.1102-1111, 2008.

T. C. Hu, R. G. Pautler, G. A. Macgowan, and A. P. Koretsky, Manganese-Enhanced MRI of Mouse Heart During Changes in Inotropy, Magn. Reson. Med, vol.46, pp.884-890, 2001.

W. Nordhoy, Manganese ions as intracellular contrast agents: proton relaxation and calcium interactions in rat myocardium, NMR Biomed, vol.16, pp.82-95, 2003.

G. A. Suero-abreu, In vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model, Neoplasia, vol.16, pp.993-1006, 2014.

J. T. Nofiele, G. J. Czarnota, and H. L. Cheng, Noninvasive Manganese-Enhanced Magnetic Resonance Imaging for Early Detection of Breast Cancer Metastatic Potential, Mol. Imaging, vol.13, 2014.

G. Baio, In vivo imaging of human breast cancer mouse model with high level expression of calcium sensing receptor at 3T, Eur. Radiol, vol.22, pp.551-558, 2012.

R. D. Braun, D. Bissig, R. North, K. S. Vistisen, and B. A. Berkowitz, Human tumor cell proliferation evaluated using manganeseenhanced MRI, PLoS One, vol.7, issue.2, p.30572, 2012.

S. Saito, Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo, Cancer Res, vol.73, issue.11, pp.3216-3224, 2013.

S. Hasegawa, Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganeseenhanced magnetic resonance imaging, Int. J. Cancer, vol.128, pp.2138-2146, 2011.

M. Seshadri and A. Hoy, Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects, Magn. Reson. Med, vol.64, pp.902-906, 2010.

T. Ganesh, R. B. Mokhtari, M. Alhamami, H. Yeger, and H. L. Cheng, Manganese-enhanced MRI of minimally gadoliniumenhancing breast tumors, J. Magn. Reson. Imaging, vol.41, pp.806-813, 2015.

M. Alhamami, Manganese-enhanced magnetic resonance imaging for early detection and characterization of breast cancers, Mol. Imaging, vol.13, pp.1-8, 2014.

N. Stikov, On the accuracy of T1 mapping: searching for common ground, Magn. Reson. Med, vol.73, pp.514-522, 2015.

P. S. Steeg, Targeting metastasis, Nature Rev. Cancer, vol.26, pp.201-218, 2016.

R. J. Weil, D. C. Palmieri, J. L. Bronder, A. M. Stark, and P. S. Steeg, Breast cancer metastasis to the central nervous system, Am. J. Pathol, vol.167, pp.913-920, 2005.

C. Harteneck, C. Klose, and D. Krautwurst, Synthetic modulators of TRP channel activity, Medicine and Biology, vol.87

B. F. Coolen, Three-dimensional T1 mapping of the mouse heart using variable flip angle steady-state MR imaging, NMR Biomed, vol.24, pp.154-162, 2011.

K. H. Chuang and A. Koretsky, Improved Neuronal Tract Tracing using Manganese Enhanced Magnetic Resonance Imaging with Fast T1 Mapping, Magn. Reson. Med, vol.55, pp.604-611, 2006.

D. B. Percy, In Vivo Characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary Magnetic Resonance Imaging approach, Inv. Radiol, vol.46, issue.11, pp.718-725, 2011.

M. Perera, In Vivo Magnetic Resonance Imaging for Investigating the Development and Distribution of Experimental Brain Metastases due to Breast Cancer, Transl. Oncol, vol.5, pp.217-225, 2012.

P. R. Lockman, Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer, Clin Cancer Res, vol.16, pp.5664-5678, 2010.

E. Aydar, S. Yeo, M. Djamgoz, and C. Palmer, Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy, Cancer Cell Int, vol.9, issue.23, 2009.

X. Ding, Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma, J. Natl. Cancer Inst, vol.102, pp.1052-1068, 2010.

A. Claes, Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment, Int. J. Cancer, vol.122, pp.1981-1986, 2008.

J. L. Sanders, Extracellular Calcium-Sensing Receptor expression and its potential role in regulating parathyroid hormonerelated peptide secretion in human breast cancer cell lines, Endocrinol, vol.141, pp.4357-4364, 2000.

E. Joeckel, High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor, Mol. Cancer, vol.13, issue.42, 2014.

F. C. Wedler and R. B. Denman, Glutamine synthetase: the major Mn (II) enzyme in mammalian brain, Curr Top Cell Regul, vol.24, pp.153-169, 1984.

E. Gianolio, MEMRI and tumors: a method for the evaluation of the contribution of Mn (II) ions in the extracellular compartment, NMR Biomed, vol.28, issue.9, pp.1104-1110, 2015.

Y. Ni, Comparison of Manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnCl 2, Acta Radiol, vol.38, pp.700-707, 1997.

E. J. Ribot, In vivo MR tracking of therapeutic microglia to a human glioma model, NMR Biomed, vol.24, pp.1361-1368, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00657909