Aromatic beta-sheet foldamers based on tertiary squaramides

Joan Atcher (1) , Aki Nagai (1) , Victor Maurizot (1) , Aya Tanatani , Ivan Huc (1)

1 CBMN - Chimie et Biologie des Membranes et des Nanoobjets

The preference of N,N-aryl, alkyl tertiary amides for cis conformations has been exploited through the use of tertiary squaramides as hairpin turn units that promote the folding of aromatic beta-sheets. Head-to-head aromatic arrangements were shown to prevail in sufficiently long bent aromatic sequences.

Domaines: Matériaux

Joan Atcher, Aki Nagai, Victor Maurizot, Aya Tanatani, Ivan Huc. Aromatic beta-sheet foldamers based on tertiary squaramides. Chemical Communications, 2019, 55 (70), pp.10392-10395. ⟨10.1039/c9cc04849a⟩. ⟨hal-03184440⟩