Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell

Abstract : Heteromeric nicotinic receptors assemble alpha and beta subunits in pentameric structures, which can adopt two stoichiometries: 3:2 or 2alpha:3beta. Both stoichiometric variants are present in the CNS, but they have never been located and characterized functionally at the level of an identified synapse. Our data indicate that 3alpha:2beta receptors are present at the spinal cord synapses between motoneurons and Renshaw cells, where their dual mode of activation (by high concentrations of ACh for synaptic receptors, by low concentrations of ACh for extrasynaptic receptors) likely accounts for the biphasic character of the synaptic current. More generally, 3alpha:2beta nicotinic receptors appear unique by their capacity to operate both in the cleft of classical synapses and at extrasynaptic locations.
Document type :
Journal articles
Complete list of metadatas

Cited literature [9 references]  Display  Hide  Download

https://hal-cnrs.archives-ouvertes.fr/hal-02323826
Contributor : Eric Krejci <>
Submitted on : Monday, October 21, 2019 - 5:59:24 PM
Last modification on : Friday, October 25, 2019 - 1:36:08 AM

File

d'Incamps et al. - 2018 - Stoi...
Files produced by the author(s)

Identifiers

Citation

Boris Lamotte D'incamps, Tamara Zorbaz, Dominika Dingová, Eric Krejci, Philippe Ascher. Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell. Journal of Neuroscience, Society for Neuroscience, 2018, 38 (21), pp.4943-4956. ⟨10.1523/JNEUROSCI.0070-18.2018⟩. ⟨hal-02323826⟩

Share

Metrics

Record views

13

Files downloads

21