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Journal Articles Journal of Neuroscience Year : 2018

Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell

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Abstract

Heteromeric nicotinic receptors assemble alpha and beta subunits in pentameric structures, which can adopt two stoichiometries: 3:2 or 2alpha:3beta. Both stoichiometric variants are present in the CNS, but they have never been located and characterized functionally at the level of an identified synapse. Our data indicate that 3alpha:2beta receptors are present at the spinal cord synapses between motoneurons and Renshaw cells, where their dual mode of activation (by high concentrations of ACh for synaptic receptors, by low concentrations of ACh for extrasynaptic receptors) likely accounts for the biphasic character of the synaptic current. More generally, 3alpha:2beta nicotinic receptors appear unique by their capacity to operate both in the cleft of classical synapses and at extrasynaptic locations.
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hal-02323826 , version 1 (21-10-2019)

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Boris Lamotte d'Incamps, Tamara Zorbaz, Dominika Neuschlová Dingová, Eric Krejci, Pauline Ascher. Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell. Journal of Neuroscience, 2018, 38 (21), pp.4943-4956. ⟨10.1523/JNEUROSCI.0070-18.2018⟩. ⟨hal-02323826⟩
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