Comment on "Relative Diffusivities of Bound and Unbound Protein Can Control Chemotactic Directionality" - Archive ouverte HAL Access content directly
Journal Articles Langmuir Year : 2022

Comment on "Relative Diffusivities of Bound and Unbound Protein Can Control Chemotactic Directionality"

, (1) ,
1
Jaime Agudo-Canalejo
  • Function : Author
Ramin Golestanian
  • Function : Author
  • PersonId : 1191007

Abstract

In a recent study 1 published in Langmuir, Mandal and Sen claim to propose a "new" kinetic model to analyze the directional movement of enzyme molecules in response to a gradient of their substrate, with the supposedly new prediction that net movement occurs up the substrate gradient when the diffusivity of the substrate-bound enzyme is lower than that of the unbound enzyme, and movement down the substrate gradient when the diffusivity of the substrate-bound enzyme is higher than that of the unbound enzyme. With the present Comment, we would like to point out that the exact same result and prediction (with an identical derivation) was already obtained by us as one of the central results in Ref. 2, whose Abstract indeed reads that we found "a new type of [chemotactic] mechanism due to binding-induced changes in the diffusion coefficient of the enzyme" which "points toward
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Dates and versions

hal-03863092 , version 1 (21-11-2022)

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  • HAL Id : hal-03863092 , version 1

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Jaime Agudo-Canalejo, Pierre Illien, Ramin Golestanian. Comment on "Relative Diffusivities of Bound and Unbound Protein Can Control Chemotactic Directionality". Langmuir, 2022. ⟨hal-03863092⟩
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