Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice - Neurosciences Paris Seine Accéder directement au contenu
Article Dans Une Revue Communications Biology Année : 2022

Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice

Résumé

Abstract Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role in the expression of female and male reproductive behavior, a mouse line lacking the ERα in the nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, and had a reduced number of progesterone receptor-immunoreactive neurons in the ventromedial hypothalamus. Mutant males displayed a moderately impaired sexual behavior and unaffected fertility, despite evidences of altered organization of sexually dimorphic populations in the preoptic area. In comparison, males deleted for both neural ERα and androgen receptor ( AR ) displayed greater sexual deficiencies. Thus, these data highlight a predominant role for neural ERα in females and a complementary role with the AR in males in the regulation of sexual behavior, and provide a solid background for future analyses of neuronal versus glial implication of these signaling pathways in both sexes.

Domaines

Neurosciences
Fichier principal
Vignette du fichier
s42003-022-03324-w.pdf (1.63 Mo) Télécharger le fichier
Origine : Publication financée par une institution
licence : CC BY - Paternité

Dates et versions

hal-04495909 , version 1 (21-11-2022)
hal-04495909 , version 2 (18-03-2024)

Identifiants

Citer

Anne-Charlotte Trouillet, Suzanne Ducroq, Lydie Naulé, Daphné Capela, Caroline Parmentier, et al.. Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice. Communications Biology, 2022, 5 (1), pp.383. ⟨10.1038/s42003-022-03324-w⟩. ⟨hal-04495909v2⟩
21 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More