Mouse arterial wall imaging and analysis from synchrotron X-ray microtomography

Xiaowen Liang (1, 2) , Aïcha Ben Zemzem (2) , Sébastien Almagro (2) , Jean-Charles Boisson (3) , Luiz Angelo Steffenel (3) , Timm Weitkamp (4) , Laurent Debelle (2) , Nicolas Passat (1)

1 CRESTIC - Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804
2 MEDyC - Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369
3 LICIIS - Laboratoire d'Informatique en Calcul Intensif et Image pour la Simulation
4 SSOLEIL - Synchrotron SOLEIL

Vascular ageing is characterized by profound modifications of the large elastic arteries (mainly aorta), leading to consequences such as aneurysm formation. Age-related diseases can be precipitated by metabolic disorders, e.g. diabetes or chronic kidney diseases. Vascular diseases involve morphological changes of the arterial extracellular matrix, particularly remodelling of the elastic lamellae found in the wall. Synchrotron X-ray microtomography (μCT) gives access to images with a micrometric resolution. In the context of vascular imaging, this allows the study of structural properties of arterial walls, even for small animals such as the mouse.

Domaines: Informatique [cs]

Xiaowen Liang, Aïcha Ben Zemzem, Sébastien Almagro, Jean-Charles Boisson, Luiz Angelo Steffenel, et al.. Mouse arterial wall imaging and analysis from synchrotron X-ray microtomography. SOLEIL Users' Meeting (SUM), Jan 2023, Saint-Aubin, France. . ⟨hal-03946851⟩