How the Acidic Milieu Interferes in the Capability of Ruthenium Nitrosyl Complexes to Release Nitric Oxide? - Laboratoire de Chimie Théorique Accéder directement au contenu
Article Dans Une Revue New Journal of Chemistry Année : 2020

How the Acidic Milieu Interferes in the Capability of Ruthenium Nitrosyl Complexes to Release Nitric Oxide?

Renato Pereira Orenha
Nelson Henrique Morgon
  • Fonction : Auteur
Graziele Cappato Guerra Silva
  • Fonction : Auteur
Glaucio Régis Nagurniak
Maurício Jeomar Piotrowski
Giovanni Finoto Caramori
Alvaro Muñoz-Castro
Renato Luis Tame Parreira

Résumé

The nitric oxide (NO) molecule is related to a large number of biological routes. Thus, there is an increased interest in improving the understanding of the NO release mechanisms. One of the traditional NO release ways involves, for example: i) [Ru(NO)(NH3)5] 3+ + e-→ [Ru(NO)(NH3)5] 2+ ; and ii) [Ru(NO)(NH3)5] 2+ + H2O → [Ru(H2O)(NH3)5] 2+ + NO, chemical reactions. Another possibility concerns to the light irradiation: iii) [Ru(NO)(NH3)5] 3+ + H2O + hν → [Ru(H2O)(NH3)5] 3+ + NO, aided by the Ru(dπ) → π * (NO) electronic transition, which decreases the π back-donation process in the Ru-NO chemical bond. The influence of the acid environment in which these chemical reactions typically occur experimentally has been explored in: iv) [Ru(NO)(NH3)5] 2+ + H3O + → [Ru(HNO)(NH3)5] 3+ + H2O; and v) [Ru(HNO)(NH3)5] 3+ + H2O → [Ru(H2O)(NH3)5] 3+ + HNO, reactions. The reaction v), supported by eight explicit water molecules, was the most propitious to occur. The HNO charge obtained from atomic polar tensor scheme is close to zero. The Quantum Theory of Atoms in Molecules and Non-Covalent Interactions methods unravel that the HNO leaving group interacts with two water molecules through partially covalent or ionic chemical bonds. The HNO→NO conversion after the release from ruthenium molecules is thermodynamically feasible. The electronic spectrum of the structure [Ru(HNO)(NH3)5] 3+ has, unlike the [Ru(NO)(NH3)5] 3+ molecule, the Ru(dπ) → π * (NO) transition with an appropriate absorbance. Therefore, the proton increases the capability of ruthenium complexes to release nitric oxide after chemical reduction reaction or of the light supported chemical reaction.

Domaines

Chimie
Fichier principal
Vignette du fichier
NO_Release_RPO_Rev2_Final.pdf (559.69 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03371961 , version 1 (09-10-2021)

Identifiants

Citer

Renato Pereira Orenha, Nelson Henrique Morgon, Julia Contreras-García, Graziele Cappato Guerra Silva, Glaucio Régis Nagurniak, et al.. How the Acidic Milieu Interferes in the Capability of Ruthenium Nitrosyl Complexes to Release Nitric Oxide?. New Journal of Chemistry, 2020, 44 (3), pp.773-779. ⟨10.1039/C9NJ04643G⟩. ⟨hal-03371961⟩
23 Consultations
52 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More