New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform

Sara Sartini (1, 2, 3, 4) , Elisabetta Levati (1, 2, 3, 4) , Martina Maccesi (5) , Matteo Guerra (1, 2, 3, 4) , Gilberto Spadoni (6) , Stéphane Bach (7, 8, 9, 10) , Monica Benincasa (11) , Marco Scocchi (11) , Simone Ottonello (1, 2, 3, 4) , Silvia Rivara (1, 2, 3, 4) , Barbara Montanini (1, 2, 3, 4)

1 UNIPR - Università degli studi di Parma = University of Parma
2 Laboratory of Functional Genomics and Protein Engineering, Biochemistry and Molecular Biology Unit, Department of Life Sciences
3 Biomolecular, Genomic and Biocomputational Sciences Unit [Parme, Italie]
4 Biopharmanet-Tec [Parme, Italie]
5 Department of Chemical and Pharmaceutical Sciences
6 Department of Biomolecular Sciences
7 SBR - Station biologique de Roscoff = Roscoff Marine Station
8 LBI2M - Laboratoire de Biologie Intégrative des Modèles Marins
9 KISSf - Plate-forme de criblage d'inhibiteurs de protéines kinases=Kinase Inhibitor Specialized Screening facility
10 FR2424 - Fédération de recherche de Roscoff
11 Department of Life Sciences [Trieste]

Domaines: Sciences du Vivant [q-bio]; Biotechnologies

Sara Sartini, Elisabetta Levati, Martina Maccesi, Matteo Guerra, Gilberto Spadoni, et al.. New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform. ACS Chemical Biology, 2019, 14 (8), pp.1727 - 1736. ⟨10.1021/acschembio.9b00178⟩. ⟨hal-03870173⟩