Emerging Roles of RNA-Binding Proteins in Inner Ear Hair Cell Development and Regeneration - Laboratoire de Biologie du Développement Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2022

Emerging Roles of RNA-Binding Proteins in Inner Ear Hair Cell Development and Regeneration

Résumé

RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level. They play major roles in the tissue- and stage-specific expression of protein isoforms as well as in the maintenance of protein homeostasis. The inner ear is a bi-functional organ, with the cochlea and the vestibular system required for hearing and for maintaining balance, respectively. It is relatively well documented that transcription factors and signaling pathways are critically involved in the formation of inner ear structures and in the development of hair cells. Accumulating evidence highlights emerging functions of RBPs in the post-transcriptional regulation of inner ear development and hair cell function. Importantly, mutations of splicing factors of the RBP family and defective alternative splicing, which result in inappropriate expression of protein isoforms, lead to deafness in both animal models and humans. Because RBPs are critical regulators of cell proliferation and differentiation, they present the potential to promote hair cell regeneration following noise- or ototoxin-induced damage through mitotic and non-mitotic mechanisms. Therefore, deciphering RBP-regulated events during inner ear development and hair cell regeneration can help define therapeutic strategies for treatment of hearing loss. In this review, we outline our evolving understanding of the implications of RBPs in hair cell formation and hearing disease with the aim of promoting future research in this field.

Domaines

Morphogenèse
Fichier principal
Vignette du fichier
ijms-23-12393.pdf (3.85 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03818545 , version 1 (18-10-2022)

Identifiants

Citer

De-Li Shi, Xiao-Ning Cheng, Audrey Saquet, Raphaëlle Grifone. Emerging Roles of RNA-Binding Proteins in Inner Ear Hair Cell Development and Regeneration. International Journal of Molecular Sciences, 2022, 23 (20), pp.12393. ⟨10.3390/ijms232012393⟩. ⟨hal-03818545⟩
31 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More