Identification of Molecular Fragments in Equilibrium with Polysiloxane Ultrasmall Nanoparticles

Identification de fragments moléculaires en équilibre avec des nanoparticules ultrasiloxanes de polysiloxane

Paul Rocchi (1, 2) , Lucie Labied (1, 3) , Tristan Doussineau (2) , Michel Julien (2) , Barbara Giroud (4) , Emmanuelle Vulliet (4) , Jérôme Randon (3) , Olivier Tillement (1) , Agnès Hagège (3) , François Lux (1, 5)

1 iLM - FENNEC - iLM - Formation, élaboration de nanomatériaux et cristaux
2 NH TherAguix SA [Meylan]
3 TechSep - ISA-Separative Methods - Techniques séparatives
4 ISA-TRACES - Technologie et Recherche en Analyse Chimique pour l'Environnement et la Santé
5 IUF - Institut universitaire de France

During recent decades, ultrasmall inorganic nanoparticles have attracted considerable interest due to their favorable biodistribution, pharmacokinetics and theranostic properties. In particular, AGuIX nanoparticles made of polysiloxane and gadolinium chelates were successfully translated to the clinics. In an aqueous medium, these nanoparticles are in dynamic equilibrium with polysiloxane fragments due to the hydrolysis of Si–O–Si bonds. Thanks to high-performance liquid chromatography coupled with electrospray ionization mass spectrometry, all these fragments were separated and identified.

Mots clés: polysiloxane; hyphenated high-performance liquid chromatography; inductively coupled plasma mass spectrometry; ultrasmall nanoparticles; theranostic; polysiloxane

Domaines: Chimie analytique; Chimie de coordination; Polymères

Paul Rocchi, Lucie Labied, Tristan Doussineau, Michel Julien, Barbara Giroud, et al.. Identification of Molecular Fragments in Equilibrium with Polysiloxane Ultrasmall Nanoparticles. Nanomaterials, 2022, 12 (5), pp.738. ⟨10.3390/nano12050738⟩. ⟨hal-03593216⟩