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Journal Articles Scientific Reports Year : 2022

Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

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Vincent Thibault
Bruno Lina
Florence Galtier
Vincent Foulongne
Odile Launay
P. Loulergue
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S. Momcilovic
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J. Mira
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N. Marin
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J. Charpentier
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A. Regent
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R. Kanaan
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F. Dumas
B. Doumenc
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M. Lachatre
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T. Szwebel
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J. Kansao
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Y. Costa
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J. Alexandra
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H. Becheur
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K. Belghalem
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J. Bernard
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A. Bleibtreu
M. Boisseau
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R. Bories
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O. Brugiere
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F. Brunet
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C. Burdet
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E. Casalino
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M. Caseris
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C. Chansiaux
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M. Chauchard
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P. Chavance
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C. Choquet
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A. Cloppet-Fontaine
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L. Colosi
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B. Couset
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B. Crestani
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F. Crocket
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A. Debit
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K Delanoe
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V. Descamps
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P. Dieude
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A. Dossier
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N. Douron
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E. Dupeyrat
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N. Emeyrat
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C. Fernet
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T. Goulenok
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S. Harent
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R. Jouenne
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A. Justet
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A. Leleu
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I. Lerat
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M. Lilamand
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A.-L. Pelletier
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L. Pereira
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P. Ralainnazava
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M. Ranaivoision
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C. Rioux
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V. Verry
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V. Vuong
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Y. Yazdapanah
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N. Houhou
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P. Géraud
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V. Driss
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V. Maugueret
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L. Crantelle
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C. Agostini
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M. Ray
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F. Letois
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T. Mura
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C. Serrand
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S. Noslier
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A. Giordano
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H. Chevassus
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E. Nyiramigisha
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C. Merle
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A. Konaté
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X. Capdevilla
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G. Du Cailar
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A. Terminet
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H. Blain
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M. Leglise
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A. Le Quellec
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P. Corne
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L. Landreau
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A. Bourgeois
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M. Sebbane
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G. Mourad
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H. Leray
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D. Postil
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E. Couve-Deacon
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M. Simon
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S. Rochas
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S. Cochennec
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E. Thébault
M. Revest
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M. Sébillotte
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Abstract

Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.
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Dates and versions

hal-03607627 , version 1 (14-03-2022)

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Attribution - CC BY 4.0

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David Luque-Paz, Pierre Tattevin, Paul Loubet, François Bénézit, Vincent Thibault, et al.. Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study. Scientific Reports, 2022, 12 (1), pp.4199. ⟨10.1038/s41598-022-08089-0⟩. ⟨hal-03607627⟩
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